Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats

MD Roberts, CB Mobley, RG Toedebush… - BMC …, 2015 - Springer
Background The purpose of this study was to investigate the effects of sub-chronic high fat,
high sucrose diet (also termed 'Westernized diet'or WD) feeding on the liver transcriptome …

Omega-3 polyunsaturated fatty acid and ursodeoxycholic acid have an additive effect in attenuating diet-induced nonalcoholic steatohepatitis in mice

JK Kim, KS Lee, DK Lee, SY Lee, HY Chang… - … & molecular medicine, 2014 - nature.com
Nonalcoholic steatohepatitis (NASH) can progress into liver cirrhosis; however, no definite
treatment is available. Omega-3 polyunsaturated fatty acid (omega-3) has been reported to …

A translational mouse model for NASH with advanced fibrosis and atherosclerosis expressing key pathways of human pathology

AM van den Hoek, L Verschuren, N Worms… - Cells, 2020 - mdpi.com
Non-alcoholic steatohepatitis (NASH) is a fast-growing liver disorder that is associated with
an increased incidence of cardiovascular disease and type 2 diabetes. Animal models …

[HTML][HTML] Hepatic transcriptome profiling reveals early signatures associated with disease transition from non-alcoholic steatosis to steatohepatitis

N Magee, F Ahamed, N Eppler, E Jones, P Ghosh… - Liver research, 2022 - Elsevier
Background and aim Non-alcoholic fatty liver disease (NAFLD) is becoming a leading cause
of chronic liver disease worldwide. The molecular events that influence disease progression …

Impact of dietary fat on the development of non-alcoholic fatty liver disease in Ldlr−/− mice

DB Jump, CM Depner, S Tripathy… - Proceedings of the …, 2016 - cambridge.org
The prevalence of non-alcoholic fatty liver disease (NAFLD) has increased in parallel with
central obesity and is now the most common chronic liver disease in developed countries …

Reduced serum cholesterol and triglyceride levels in a choline-deficient L-Amino acid-defined high-fat diet (CDAHFD)-induced mouse model of non-alcoholic …

D Yasuda, H Torii, R Shimizu, Y Hiraoka… - Biological and …, 2020 - jstage.jst.go.jp
Non-alcoholic fatty liver disease (NAFLD) or non-alcoholic seatohepatitis (NASH) is one of
the major health problems world wide, because of increased abdominal obesity. To date …

[HTML][HTML] Model of nonalcoholic steatohepatitis

CS Lieber, MA Leo, KM Mak, Y Xu, Q Cao… - The American journal of …, 2004 - Elsevier
Background Obesity and diabetes are frequently associated with nonalcoholic
steatohepatitis (NASH), but studies have been hampered by the absence of a suitable …

Multi-technique comparison of atherogenic and MCD NASH models highlights changes in sphingolipid metabolism

SA Montandon, E Somm, U Loizides-Mangold… - Scientific reports, 2019 - nature.com
Lipotoxicity is a key player in the pathogenesis of nonalcoholic steatohepatitis (NASH), a
progressive subtype of nonalcoholic fatty liver disease (NAFLD). In the present study, we …

Unraveling hepatic metabolomic profiles and morphological outcomes in a hybrid model of NASH in different mouse strains

GP Bacil, GR Romualdo, PMFD Piagge, DR Cardoso… - Antioxidants, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) encompasses nonalcoholic steatohepatitis (NASH)
and affects 25% of the global population. Although a plethora of experimental models for …

Development of nonalcoholic steatohepatitis model through combination of high-fat diet and tetracycline with morbid obesity in mice

M Ito, J Suzuki, M Sasaki, K Watanabe, S Tsujioka… - Hepatology …, 2006 - Elsevier
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease closely associated with
obesity, type 2 diabetes and hyperlipidemia. For further understanding of NASH …