Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
V Mixão, JC Nunez-Rodriguez, V Del Olmo… - BMC biology, 2023 - Springer
Background Hybrids are chimeric organisms with highly plastic heterozygous genomes that
may confer unique traits enabling the adaptation to new environments. However, most …
may confer unique traits enabling the adaptation to new environments. However, most …
The transcriptional aftermath in two independently formed hybrids of the opportunistic pathogen Candida orthopsilosis
Interspecific hybridization can drive evolutionary adaptation to novel environments. The
Saccharomycotina clade of budding yeasts includes many hybrid lineages, and …
Saccharomycotina clade of budding yeasts includes many hybrid lineages, and …
Genomic evidence for a hybrid origin of the yeast opportunistic pathogen Candida albicans
V Mixão, T Gabaldón - BMC biology, 2020 - Springer
Background Opportunistic yeast pathogens of the genus Candida are an important medical
problem. Candida albicans, the most prevalent Candida species, is a natural commensal of …
problem. Candida albicans, the most prevalent Candida species, is a natural commensal of …
Loss of heterozygosity in commensal isolates of the asexual diploid yeast Candida albicans
D Diogo, C Bouchier, C d'Enfert… - Fungal Genetics and …, 2009 - Elsevier
Candida albicans is a commensal and the most frequent fungal pathogen of humans. One
mechanism of genetic variation in this diploid asexual yeast involves loss of heterozygosity …
mechanism of genetic variation in this diploid asexual yeast involves loss of heterozygosity …
Patterns of genomic instability in interspecific yeast hybrids with diverse ancestries
The genomes of hybrids often show substantial deviations from the features of the parent
genomes, including genomic instabilities characterized by chromosomal rearrangements …
genomes, including genomic instabilities characterized by chromosomal rearrangements …
[HTML][HTML] Hybrids unleashed: exploring the emergence and genomic insights of pathogenic yeast hybrids
V Del Olmo, T Gabaldón - Current Opinion in Microbiology, 2024 - Elsevier
Highlights•Hybridisation is the crossing of divergent lineages.•Hybridisation in pervasive in
Saccharomycotina yeasts.•It is a source of genetic diversity, shapes evolution and …
Saccharomycotina yeasts.•It is a source of genetic diversity, shapes evolution and …
Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata
S Poláková, C Blume, JÁ Zárate… - Proceedings of the …, 2009 - National Acad Sciences
In eukaryotes, the number and rough organization of chromosomes is well preserved within
isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent …
isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent …
A yeast love triangle: multiple hybridizations shape genome evolution in the Pichia cactophila species complex.
Hybrids are chimeric organisms carrying genetic material from at least two divergent
parental lineages. Hybridization can contribute to the emergence of novel lineages with …
parental lineages. Hybridization can contribute to the emergence of novel lineages with …
Hybridization and emergence of virulence in opportunistic human yeast pathogens
V Mixão, T Gabaldón - Yeast, 2018 - Wiley Online Library
Hybridization between different species can result in the emergence of new lineages and
adaptive phenotypes. Occasionally, hybridization in fungal organisms can drive the …
adaptive phenotypes. Occasionally, hybridization in fungal organisms can drive the …
Stress-Induced Loss of Heterozygosity in Candida: a Possible Missing Link in the Ability to Evolve
SM Rosenberg - MBio, 2011 - Am Soc Microbiol
Diploid organisms are buffered against the effects of mutations by carrying two sets of each
gene, which allows compensation if one is mutated. But recombination between “mom” and …
gene, which allows compensation if one is mutated. But recombination between “mom” and …
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