Cardiovascular diseases and depression are significant health burdens and increasing
evidence suggests a causal relationship between them. The incidence of depression among …

Serotonin is an important neurohormonal factor that has been implicated in cardiovascular
function. It can regulate vascular tone, act directly on cardiomyocytes and stimulate …

Serotonergic dysfunction is mainly associated with neuropsychiatric and cardiovascular
disorders but has also been linked with many other pathological conditions. This review …

5-Hydroxytryptamine (5-HT; serotonin) was discovered more than 60 years ago as a
substance isolated from blood. The neural effects of 5-HT have been well investigated and …

Serotonin [5-hydroxytryptamine (5-HT)] is an amine made from the essential amino acid
tryptophan. 5-HT serves numerous functions in the body, including mood, satiety, and …

Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The
effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as …

The present article deals with the pathophysiological role of serotonin in cardiovascular
disease and in other disorders that are accompanied by cardiovascular pathophysiological …

Summary Plasma 5-hydroxytryptamine (5-HT; serotonin), released from blood platelets,
plays a major role in the human cardiovascular system. Besides the effect of endogenous …

All 5-hydroxytryptamine (5-HT; serotonin) receptors, except the 5-HT 6 type, have been
shown to be involved in cardiovascular regulation. In the periphery, 5-HT is stored in …

Pleiotropic effects of serotonin (5-HT) in the cardiovascular system are well documented.
However, it remains to be elucidated, whether 5-HT is present in adult mammalian …