Among the most widely used models of Parkinson's disease (PD) are those that employ
toxins, especially 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Depending on the …

Experimental models of dopaminergic neurodegeneration play a critical role in our quest to
elucidate the cause of Parkinson's disease (PD). Despite the recent development of “genetic …

The biochemical and cellular changes that occur following administration of 1-methyl-4-
phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic …

1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) has been used as a potent
neurotoxin to approximate, in animals, the pathology that is observed in human Parkinson's …

Animal models are a very important approach to study the pathogenesis and therapeutic
intervention strategies of human diseases. Since many human disorders do not arise …

Parkinson's disease (PD) is a common neurodegenerative disorder, characterized by the
progressive loss of dopaminergic neurons in the substantia nigra. Although valuable animal …

This protocol describes our method of producing a reliable mouse model of Parkinson's
disease (PD) using the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) …

Animal models play a critical role in our understanding of the cause of human diseases and
provide an opportunity to evaluate new therapeutic treatments. The usefulness of an animal …

Formidable challenges for Parkinson's disease (PD) research are to understand the
processes underlying nigrostriatal degeneration and how to protect dopamine neurons …

In mice, the systemical or intracranial application of the neurotoxin 1-methyl-4-phenyl-1, 2, 3,
6-tetrahydropyridine (MPTP) can lead to severe damage to the nigrostriatal dopaminergic …