Oxidative stress (OS) plays, perhaps, the most important role in the advanced aging process,
cognitive impairment and pathogenesis of neurodegenerative disorders. The process …

Brain ageing leads to a series of changes that reduce the processes of adaptation and
response. These transformations can end in cognitive impairment and/or dementia …

Numerous physiological and pathological conditions are related to the augmentation of
oxidative stress. The weakened antioxidant defense and the increased production of …

It is considered that reactive oxygen species (ROS) and free radicals in general, are
involved in a variety of physiological and pathological processes including degenerative …

Most evidence indicates that aging is a result of normal metabolic processes that are
essential for life. Thus, an important approach in biogerontology is to identify specific …

The world population is aging rapidly, and increasing lifespan exacerbates the burden of
age-related health issues. On the other hand, premature aging has begun to be a problem …

Oxidative stress in brain is emerging as a potential causal factor in aging and age-related
neurodegenerative disorders. Brain tissue from living patients is difficult to acquire; hence …

ROS were long considered one of the key players in tissue injury. Indeed, overproduction of
ROS results in oxidative stress, a process leading to the development of many pathological …

Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …

Neurologists have highly observed a frequent increasing number of elderly patients with
Alzheimer's disease (AD) without any relevant evidence of any genetic or known AD‐linked …