Migration of monocytes-macrophages plays an important role in phagocytosis of pathogens
and cellular debris in a variety of pathophysiological conditions. Although epithelial Na+ …

The epithelial sodium channel (ENaC) is a heterotrimer and is widely distributed throughout
the kidneys, blood vessels, lungs, colons, and many other organs. The basic role of the …

Acute lung injury (ALI) is a devastating syndrome characterized by diffuse alveolar damage,
elevated airspace levels of pro-inflammatory cytokines, and flooding of the alveolar spaces …

An increasing number of mechano-sensitive ion channels in endothelial cells have been
identified in response to blood flow and hydrostatic pressure. However, how these channels …

Voltage-gated sodium channels expressed on the plasma membrane activate rapidly in
response to changes in membrane potential in cells with excitable membranes such as …

Background Epithelial cells are exposed to a variety of mechanical stimuli. Epithelial Na+
channels (ENaC) mediate sodium transport across apical membranes of epithelial cells that …

Intra-amniotic exposure to proinflammatory cytokines such as interleukin-1 (IL-1) correlates
with a decreased incidence of respiratory distress syndrome (RDS) in infants following …

The remarkable architecture of our airways, with 23 levels of branching from the trachea to
the approximately 600 million alveoli in an adult lung, accounts for an alveolar epithelial …

Recent reports have shown that cytokines inhibit fluid absorption by suppressing Na+
channel activity in various epithelia. In this study, we investigated the role of epithelial …

Sodium influx mediated by ion channels of plasma membrane underlies fundamental
physiological processes in cells of blood origin. However, little is known about the single …