In recent years, several important advances have been made in our understanding of the
pathways that lead to cell dysfunction and death in Parkinson's disease (PD) and …

Maintaining the functional integrity of mitochondria is pivotal for cellular survival. It appears
that neuronal homeostasis depends on high-fidelity mitochondria, in particular …

As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

The human brain is a highly complex organ with remarkable energy demands. Although it
represents only 2% of the total body weight, it accounts for 20% of all oxygen consumption …

Neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and
amyotrophic lateral sclerosis, are characterized by a progressive loss of selective neuron …

The mitochondrion is a unique organelle with a diverse range of functions. Mitochondrial
dysfunction is a key pathological process in several neurodegenerative diseases …

Neuronal survival critically depends on the integrity and functionality of mitochondria. A
hierarchical system of cellular surveillance mechanisms protects mitochondria against …

Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

Fundamental organelles that occur in every cell type with the exception of mammal
erythrocytes, the mitochondria are required for multiple pivotal processes that include the …

Mitochondria function differently in aged brains than they do in young brains. Consistently
reported changes include reduced electron transport chain (ETC) enzyme activities, reduced …