In recent years, several studies have examined the potential associations between
mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS) …

With the current explosion of knowledge on the role of mitochondrial dysfunction in the
genesis of various human disease states, there is an increased interest in targeting …

Parkinson disease (PD) is associated with progressive loss of dopaminergic neurons in the
substantia nigra, as well as with more-widespread neuronal changes that cause complex …

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Neurodegenerative diseases (NDs) are the group of disorder that includes brain, peripheral
nerves, spinal cord and results in sensory and motor neuron dysfunction. Several studies …

As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

Mitochondria are essential organelles for neuronal function and cell survival. Besides the
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …

Mitochondrial dysfunction has long been associated with Parkinson's disease (PD). In
particular, complex I impairment and subsequent oxidative stress have been widely …

A growing body of evidence suggests that mitochondrial abnormalities are involved in aging
and in age-related neurodegenerative diseases as well as cancer, diabetes, and several …

Alzheimer disease (AD) and Parkinson disease (PD) are the two most common age-related
neurodegenerative diseases characterized by prominent neurodegeneration in selective …