Background Cortisol-producing adrenocortical adenoma (CPA) during pregnancy rarely
occurs in clinic. Growing evidence suggests that DNA methylation plays a key role in …

DNA methylation and demethylation regulate the transcription of genes. DNA methylation-
associated gene expression of adrenal steroidogenic enzymes may regulate cortisol …

Patients with congenital adrenal hyperplasia (CAH) are at risk of long-term cognitive and
metabolic sequelae with some of the effects being attributed to the chronic glucocorticoid …

Objective: DNA methylation is an important epigenetic regulator of gene transcription, and is
involved in many diseases, which has been researched recently. In this study, we aimed to …

Aberrant DNA methylation may be involved in human adrenocortical tumorigenesis, which is
often accompanied by abnormal hormone production. In this study, we aimed to clarify the …

Background Corticotropin-releasing hormone (CRH) plays a central role in regulating the
secretion of cortisol which controls a wide range of biological processes. Fetuses …

Context: It is not known whether there are any DNA methylation alterations in adrenocortical
tumors. Objective: The objective of the study was to determine the methylation profile of …

Background: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an
unfavorable prognosis and limited treatment options. Nevertheless, no clinically applicable …

Background A small number of recent reports have suggested that altered placental DNA
methylation may be associated with early onset preeclampsia. It is important that further …

Placental cortisol is inactivated in normotensive pregnancies, but is frequently present in pre-
eclampsia associated placentae. Since glucocorticoids are strongly associated with the …