Ketamine: an update on cellular and subcellular mechanisms with implications for clinical practice
GJ Iacobucci, O Visnjevac, L Pourafkari… - Pain …, 2017 - search.proquest.com
BACKGROUND: Ketamine is one of the oldest hypnotic agents used to provide an
anesthetic agent with analgesic properties and minimal suppressive effects on respiration …
anesthetic agent with analgesic properties and minimal suppressive effects on respiration …
An update on the basic and clinical science of ketamine analgesia
LV Doan, J Wang - The Clinical journal of pain, 2018 - journals.lww.com
Objective: In the context of the current opioid epidemic, there has been a renewed interest in
the use of ketamine as an analgesic agent. Methods: We reviewed ketamine analgesia …
the use of ketamine as an analgesic agent. Methods: We reviewed ketamine analgesia …
Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms
S Kohtala - Pharmacological Reports, 2021 - Springer
Over the past 50 years, ketamine has solidified its position in both human and veterinary
medicine as an important anesthetic with many uses. More recently, ketamine has been …
medicine as an important anesthetic with many uses. More recently, ketamine has been …
Ketamine: 50 years of modulating the mind
L Li, PE Vlisides - Frontiers in human neuroscience, 2016 - frontiersin.org
Ketamine was introduced into clinical practice in the 1960s and continues to be both
clinically useful and scientifically fascinating. With considerably diverse molecular targets …
clinically useful and scientifically fascinating. With considerably diverse molecular targets …
Ketamine: repurposing and redefining a multifaceted drug
DE Potter, M Choudhury - Drug Discovery Today, 2014 - Elsevier
Highlights•Ketamine is an established dissociative anesthetic.•Ketamine's primary action
involves inhibition of N-methyl-D-aspartate (NMDA) receptors.•Ketamine also modulates …
involves inhibition of N-methyl-D-aspartate (NMDA) receptors.•Ketamine also modulates …
Application of ketamine in pain management and the underlying mechanism
X Ma, J Yan, H Jiang - Pain Research and Management, 2023 - Wiley Online Library
Since ketamine was approved by the FDA as an intravenous anesthetic, it has been in
clinical use for more than 50 years. Apart from its anesthetic effects, ketamine is one of the …
clinical use for more than 50 years. Apart from its anesthetic effects, ketamine is one of the …
A review of nonanesthetic uses of ketamine
A Pribish, N Wood, A Kalava - Anesthesiology research and …, 2020 - Wiley Online Library
Ketamine, a nonselective NMDA receptor antagonist, is used widely in medicine as an
anesthetic agent. However, ketamine's mechanisms of action lead to widespread …
anesthetic agent. However, ketamine's mechanisms of action lead to widespread …
[PDF][PDF] Ketamine: Mechanisms, Applications, and Future Directions
I Karunarathna, K Kusumarathna… - Uva Clinical Lab …, 2024 - researchgate.net
Ketamine, a versatile anesthetic agent with a complex pharmacological profile, has been
utilized in clinical practice for decades3. This review examines the diverse mechanisms of …
utilized in clinical practice for decades3. This review examines the diverse mechanisms of …
Ketamine: an old drug revitalized in pain medicine
PY Tsui, MC Chu - BJA Education, 2017 - academic.oup.com
Ketamine is an anaesthetic drug with unique properties. Discovered in the 1960s, it is known
to produce a dissociative state with sedation, amnesia, and analgesia. It has relatively less …
to produce a dissociative state with sedation, amnesia, and analgesia. It has relatively less …
Ketamine in the past, present, and future: mechanisms, metabolites, and toxicity
ES Schwenk, B Pradhan, R Nalamasu, L Stolle… - Current pain and …, 2021 - Springer
Abstract Purpose of Review While ketamine's analgesia has mostly been attributed to
antagonism of N-methyl-d-aspartate receptors, evidence suggests multiple other pathways …
antagonism of N-methyl-d-aspartate receptors, evidence suggests multiple other pathways …