Vacuoles are dynamic cellular organelles, and their morphology is altered by various stimuli
or stresses. Vacuoles play an important role in the physiology and virulence of many fungal …

Cryptococcus neoformans is an encapsulated yeast pathogen that infects
immunocompromised patients to cause fungal meningitis, resulting in hundreds of …

We studied superoxide dismutases (SODs) in the encapsulated yeast Cryptococcus
neoformans (Cn) variety gattii to analyse the role of mitochondrial MnSOD (SOD2) in fungal …

Manganese superoxide dismutase is an essential component of the mitochondrial
antioxidant defense system of most eukaryotes. In the present study, we used a reverse …

Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved
by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a …

Cryptococcus neoformans is a facultative intracellular pathogen and its interaction with
macrophages is a key event determining the outcome of infection. Urease is a major …

Superoxide dismutase (SOD) is an enzyme that converts superoxide radicals into hydrogen
peroxide and molecular oxygen and has been shown to contribute to the virulence of many …

Small molecules are components of fungal extracellular vesicles (EVs), but their biological
roles are only superficially known. NOP16 is a eukaryotic gene that is required for the activity …

Cryptococcus neoformans produces extracellular vesicles containing a variety of cargo,
including virulence factors. To become extracellular, these vesicles not only must be …

Ubiquitination is a reversible protein modification that influences various cellular processes
in eukaryotic cells. Deubiquitinating enzymes remove ubiquitin, maintain ubiquitin …