Ubiquitination is a reversible protein modification that influences various cellular processes
in eukaryotic cells. Deubiquitinating enzymes remove ubiquitin, maintain ubiquitin …

Fungal infections are on the rise, with mortality above 30% in patients with septic Candida
infections. Mutants lacking V-ATPase activity are avirulent and fail to acidify endomembrane …

Acidification of vesicular compartments plays an important role in a number of cellular
transport processes, including protein secretion, metal cofactor insertion, glycosylation and …

Cryptococcus neoformans is an opportunistic fungal pathogen whose pathogenic lifestyle is
linked to its ability to cope with fluctuating levels of copper (Cu), an essential metal involved …

Cryptococcus neoformans is a facultative intracellular pathogen. The most distinctive feature
of C. neoformans is a polysaccharide capsule that enlarges depending on environmental …

Previous studies have demonstrated an important role for the vacuole in the virulence of the
fungus Cryptococcus and studies in yeast have implicated the vacuolar protein Vps41 in …

Due to its location, the fungal cell wall is the compartment that allows the interaction with the
environment and/or the host, playing an important role during infection as well as in different …

Small molecules are components of fungal extracellular vesicles (EVs), but their biological
roles are only superficially known. NOP16 is a eukaryotic gene that is required for the activity …

Cryptococcus neoformans is a facultative intracellular pathogen that can replicate and
disseminate in mammalian macrophages. In this study, we analyzed fungal proteins …

The pathogenic yeast Cryptococcus neoformans (Cn) var. gattii causes meningoencephalitis
in healthy individuals, unlike the better known Cn varieties grubii and neoformans, which are …