Prostate cancer is the second most common malignancy affecting men worldwide, and the
commonest affecting men of African descent. Significant diagnostic and therapeutic …

Improvements in DNA sequencing technology and discoveries made by large scale genome-
wide association studies have led to enormous insight into the role of genetic variation in …

Simple Summary The potential importance of germline genetic variation for identifying men
at increased risk of prostate cancer has become increasingly recognised in recent years. We …

Established risk factors for prostate cancer include age, ethnicity, a family history of prostate
cancer or carrying a pathogenic germline variation in a prostate cancer predisposition gene …

Abstract Purpose of Review Prostate cancer (PrCa) is the most common cancer in men in
the western world and is a major source of morbidity and mortality. Currently, general …

Most criteria for genetic testing for prostate cancer susceptibility require a prior diagnosis of
prostate cancer, in particular cases with metastatic disease are selected. Advances in the …

Prostate cancer heritability is attributed to a combination of rare, moderate to highly
penetrant genetic variants as well as commonly occurring variants conferring modest risks …

Prostate cancer (PrCa) is the most commonly diagnosed cancer in the male UK population,
with over 40,000 new cases per year. PrCa has a complex, polygenic predisposition, due to …

BACKGROUND One of the difficulties confronting genetic studies of prostate cancer is the
complex and heterogeneous etiology. Given the high population frequency of lesions …

Prostate cancer fulfils some of the conditions required of a disease that might be managed
by population screening. In a cohort of 50-to 60-year-old men, carrying out a rectal …