Neurokinin receptors belong to the GPCRs family and are ubiquitously expressed
throughout the nervous and immune systems. Neurokinin receptors in coordination with …

The neurokinin 1 receptor with the natural substrate substance P is one of the intensely
studied receptors among the neurokinin receptors. The intracellular signaling mechanism …

The recent years have witnessed an exponential increase in cancer research, leading to a
considerable investment in the field. However, with few exceptions, this effort has not yet …

The precise nature of neurokin receptor involvement in human immune cell chemotaxis is
unclear. This study therefore sought to directly compare the chemotactic effects of …

Background Tachykinins and their cognate receptors, neurokinin receptors (NKs) including
NK1, NK2, and NK3 play vital roles in regulating various physiological processes including …

The neurokinin 1 receptor (NK‐1R) is the main receptor for the tachykinin family of peptides.
Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is …

Substance P is the prototype tachykinin peptide and triggers a variety of biological effects in
both the nervous and immune system. Two naturally occurring variants of the neurokinin 1 …

The G protein–coupled receptor (GPCR), neurokinin‐1 receptor (NK1R), and its preferred
ligand, substance P (SP), are reviewed in relationship to the immune system and selected …

The central function of the immune system is to protect the host from environmental agents
such as microbes or chemicals, thereby preserving the integrity of the body, and preventing …

The mammalian tachykinins (substance P, neurokinin A, and neurokinin B) are widely
distributed throughout the central and peripheral nervous systems, where they act as …