Traumatic brain injury is increasingly common in older individuals. Older age is one of the
strongest predictors for poor prognosis after brain trauma, a phenomenon driven by the …

Initial studies suggest that increased age is associated with worse outcomes after traumatic
brain injury (TBI), though the pathophysiological mechanisms responsible for this remain …

Increasing evidence demonstrates that aging influences the brain's response to traumatic
brain injury (TBI), setting the stage for neurodegenerative pathology like Alzheimer's disease …

Background Older-age individuals are at the highest risk for disability from a traumatic brain
injury (TBI). Astrocytes are the most numerous glia in the brain, necessary for brain function …

After traumatic brain injury (TBI), individuals aged over 65 years show increased mortality
and worse functional outcomes compared with younger persons. As neuroinflammation is a …

As mitigation of brain aging continues to be a key public health priority, a wholistic and
comprehensive consideration of the aging body has identified immunosenescence as a …

The peripheral immune system plays a critical role in aging and in the response to brain
injury. Emerging data suggest inflammatory responses are exacerbated in older animals …

Background Traumatic brain injury (TBI) in older adults leads to considerable morbidity and
mortality. Outcomes among older adults with TBI are disparately worse than in younger …

Traumatic brain injury (TBI) is of particular concern for the aging community since there is
both increased incidence of TBI and decreased functional recovery in this population. In …

Aged traumatic brain injury (TBI) patients suffer increased mortality and long-term
neurocognitive and neuropsychiatric morbidity compared with younger patients. Microglia …