Ageing is associated with maladaptive immune response and worse outcome after traumatic brain injury
Traumatic brain injury is increasingly common in older individuals. Older age is one of the
strongest predictors for poor prognosis after brain trauma, a phenomenon driven by the …
strongest predictors for poor prognosis after brain trauma, a phenomenon driven by the …
Aged rats have an altered immune response and worse outcomes after traumatic brain injury
M Sun, RD Brady, PM Casillas-Espinosa… - Brain, behavior, and …, 2019 - Elsevier
Initial studies suggest that increased age is associated with worse outcomes after traumatic
brain injury (TBI), though the pathophysiological mechanisms responsible for this remain …
brain injury (TBI), though the pathophysiological mechanisms responsible for this remain …
A levee to the flood: pre-injury neuroinflammation and immune stress influence traumatic brain injury outcome
S Houle, ON Kokiko-Cochran - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Increasing evidence demonstrates that aging influences the brain's response to traumatic
brain injury (TBI), setting the stage for neurodegenerative pathology like Alzheimer's disease …
brain injury (TBI), setting the stage for neurodegenerative pathology like Alzheimer's disease …
Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice
AN Early, AA Gorman, LJ Van Eldik… - Journal of …, 2020 - Springer
Background Older-age individuals are at the highest risk for disability from a traumatic brain
injury (TBI). Astrocytes are the most numerous glia in the brain, necessary for brain function …
injury (TBI). Astrocytes are the most numerous glia in the brain, necessary for brain function …
Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice
After traumatic brain injury (TBI), individuals aged over 65 years show increased mortality
and worse functional outcomes compared with younger persons. As neuroinflammation is a …
and worse functional outcomes compared with younger persons. As neuroinflammation is a …
Role of B cells and the aging brain in stroke recovery and treatment
As mitigation of brain aging continues to be a key public health priority, a wholistic and
comprehensive consideration of the aging body has identified immunosenescence as a …
comprehensive consideration of the aging body has identified immunosenescence as a …
Aging alters the immunological response to ischemic stroke
The peripheral immune system plays a critical role in aging and in the response to brain
injury. Emerging data suggest inflammatory responses are exacerbated in older animals …
injury. Emerging data suggest inflammatory responses are exacerbated in older animals …
Traumatic brain injury in aged mice induces chronic microglia activation, synapse loss, and complement-dependent memory deficits
Traumatic brain injury (TBI) is of particular concern for the aging community since there is
both increased incidence of TBI and decreased functional recovery in this population. In …
both increased incidence of TBI and decreased functional recovery in this population. In …
Traumatic brain injury induces an adaptive immune response in the meningeal transcriptome that is amplified by aging
Traumatic Brain Injury (TBI) is a major cause of disability and mortality, particularly among
the elderly, yet our mechanistic understanding of how age renders the post-traumatic brain …
the elderly, yet our mechanistic understanding of how age renders the post-traumatic brain …
Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury
S Kyrkanides, MK O'Banion, PE Whiteley… - Journal of …, 2001 - Elsevier
Aging is associated with increased glial responsiveness that may enhance the brain's
susceptibility to injury and disease. To determine whether unique age-related molecular …
susceptibility to injury and disease. To determine whether unique age-related molecular …