Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Age-related
TBI differences demonstrate the third peak of prevalence and incidence of TBI within the …

The relationship between heightened neuroinflammation and cognitive decline in the
normally aged brain is still debatable, as most data are derived from insult-related models …

Background Increased age is a major risk factor for stroke incidence, post-ischemic mortality,
and severe and long-term disability. Stroke outcome is considerably influenced by post …

Neuroinflammation is associated with glial activation following a variety of brain injuries,
including stroke. While activation of perilesional astrocytes and microglia following ischemic …

Microglia, the innate immune cells of the brain, develops a pro‐inflammatory,“primed” profile
with age. Using single‐cell RNA‐sequencing, we confirmed hippocampal microglia of aged …

Aging coincides with major changes in brain immunity that aid in a decline in neuronal
function. Here, we postulate that systemic, pro-aging factors contribute to immunological …

In the hours to days after intracerebral hemorrhage (ICH), there is an inflammatory response
within the brain characterized by the infiltration of peripheral neutrophils and macrophages …

Background Microglia function is essential to maintain the brain homeostasis. Evidence
shows that aged microglia are primed and show exaggerated response to acute …

Traumatic brain injury (TBI) is an ever growing health concern, with cases increasing in both
the US and the world at large. With the improvement of emergency medicine in recent …

Neurodegenerative diseases of the central nervous system (CNS) are characterized by
progressive neuronal death and neurological dysfunction, leading to increased disability …