Intercellular communication refers to the different ways through which cells communicate
with each other and transfer a variety of messages. These communication methods involve a …

Mammalian cells mostly rely on extracellular molecules to transfer signals to other cells.
However, in stress conditions, more robust mechanisms might be necessary to facilitate cell …

Highlights•Interconnectivity and homeostatic feedback are fundamental properties of
biological systems.•Specific nodes in the interconnected network of an organism are more …

Cellular senescence is the final fate of most cells in response to specific stimuli, but is not the
end. Indeed, it is the beginning of a singular life, with multiple side roads leading to diverse …

Our cells are comprised of billions of proteins, lipids, and other small molecules packed into
their respective subcellular organelles, with the daunting task of maintaining cellular …

Organismal aging is often characterized as a steady, monotonic decline of organ and tissue
function. However, recent studies indicate spatial and temporal variations of aging rates …

Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Cellular senescence is a proliferation arrest that is typically irreversible and caused by
various cellular stresses, including excess rounds of cell division and cancer-causing …

Chronic inflammation is associated with aging and plays a causative role in several age-
related diseases such as cancer, atherosclerosis and osteoarthritis. The source of this …