Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery
Hyperglycemia and hyperlipidemia are often observed in individuals with type II diabetes
(T2D) and related mouse models. One dysmetabolic biochemical consequence is the non …
(T2D) and related mouse models. One dysmetabolic biochemical consequence is the non …
Metabolomics and lipidomics study of mouse models of type 1 diabetes highlights divergent metabolism in purine and tryptophan metabolism prior to disease onset
SA Murfitt, P Zaccone, X Wang, A Acharjee… - Journal of proteome …, 2018 - ACS Publications
With the increase in incidence of type 1 diabetes (T1DM), there is an urgent need to
understand the early molecular and metabolic alterations that accompany the autoimmune …
understand the early molecular and metabolic alterations that accompany the autoimmune …
The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice
MAJ Morgan, PSS Muller, A Mould, SA Newland… - PloS one, 2013 - journals.plos.org
The spontaneous destruction of insulin producing pancreatic beta cells in non-obese
diabetic (NOD) mice provides a valuable model of type 1 diabetes. As in humans, disease …
diabetic (NOD) mice provides a valuable model of type 1 diabetes. As in humans, disease …
PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes
A diet rich in saturated fat and carbohydrates causes low-grade chronic inflammation in
several organs, including the liver, ultimately driving nonalcoholic steatohepatitis. In this …
several organs, including the liver, ultimately driving nonalcoholic steatohepatitis. In this …
Making insulin and staying out of autoimmune trouble: the beta-cell conundrum
Autoimmune type 1 diabetes (T1D) results from the intricate crosstalk of various immune cell
types. CD8+ T cells dominate the pro-inflammatory milieu of islet infiltration (insulitis), and …
types. CD8+ T cells dominate the pro-inflammatory milieu of islet infiltration (insulitis), and …
Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications
Abstract Background Type 1 diabetes (T1D) is thought to be an autoimmune disease driven
by anti-islet antigen responses and mediated by T-cells. Recent published data suggests …
by anti-islet antigen responses and mediated by T-cells. Recent published data suggests …
Position β57 of IAg7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset
L Gioia, M Holt, A Costanzo, S Sharma, B Abe… - Science …, 2019 - science.org
The class II region of the major histocompatibility complex (MHC) locus is the main
contributor to the genetic susceptibility to type 1 diabetes (T1D). The loss of an aspartic acid …
contributor to the genetic susceptibility to type 1 diabetes (T1D). The loss of an aspartic acid …
Using mass spectrometry to identify neoantigens in autoimmune diseases: the type 1 diabetes example
In autoimmune diseases, recognition of self-antigens presented by major histocompatibility
complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or …
complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or …
Roles for major histocompatibility complex glycosylation in immune function
SO Ryan, BA Cobb - Seminars in immunopathology, 2012 - Springer
The major histocompatibility complex (MHC) glycoprotein family, also referred to as human
leukocyte antigens, present endogenous and exogenous antigens to T lymphocytes for …
leukocyte antigens, present endogenous and exogenous antigens to T lymphocytes for …
Conventional and neo-antigenic peptides presented by β cells are targeted by circulating naïve CD8+ T cells in type 1 diabetic and healthy donors
S Gonzalez-Duque, ME Azoury, ML Colli, G Afonso… - Cell metabolism, 2018 - cell.com
Summary Although CD8+ T-cell-mediated autoimmune β cell destruction occurs in type 1
diabetes (T1D), the target epitopes processed and presented by β cells are unknown. To …
diabetes (T1D), the target epitopes processed and presented by β cells are unknown. To …