β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca2+-permeable AMPA receptors
JL Sanderson, RK Freund, JA Gorski, ML Dell'Acqua - Cell reports, 2021 - cell.com
Regulated insertion and removal of postsynaptic AMPA glutamate receptors (AMPARs)
mediates hippocampal long-term potentiation (LTP) and long-term depression (LTD) …
mediates hippocampal long-term potentiation (LTP) and long-term depression (LTD) …
Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity
D Azarnia Tehran, G Kochlamazashvili… - Science …, 2022 - science.org
AMPA-type glutamate receptors (AMPARs) mediate fast excitatory neurotransmission, and
the plastic modulation of their surface levels determines synaptic strength. AMPARs of …
the plastic modulation of their surface levels determines synaptic strength. AMPARs of …
[HTML][HTML] Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity
G Kochlamazashvili, NP Pampaloni, S Sposini… - Science …, 2022 - ncbi.nlm.nih.gov
AMPA-type glutamate receptors (AMPARs) mediate fast excitatory neurotransmission, and
the plastic modulation of their surface levels determines synaptic strength. AMPARs of …
the plastic modulation of their surface levels determines synaptic strength. AMPARs of …
[HTML][HTML] Amyloid-β oligomers suppress subunit-specific glutamate receptor increase during LTP
H Tanaka, D Sakaguchi, T Hirano - Alzheimer's & Dementia: Translational …, 2019 - Elsevier
Introduction Amyloid-β oligomers (AβOs) are assumed to impair the ability of learning and
memory by suppressing the induction of synaptic plasticity, such as long-term potentiation …
memory by suppressing the induction of synaptic plasticity, such as long-term potentiation …
Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca2+-Permeable AMPA Receptors
RW Livingstone, MK Elder, A Singh… - Frontiers in Molecular …, 2021 - frontiersin.org
Regulation of AMPA receptor expression by neuronal activity and neuromodulators is critical
to the expression of both long-term potentiation (LTP) and memory. In particular, Ca2+ …
to the expression of both long-term potentiation (LTP) and memory. In particular, Ca2+ …
AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors
JL Sanderson, JA Gorski, ES Gibson… - Journal of …, 2012 - Soc Neuroscience
AMPA receptors (AMPARs) are tetrameric ion channels assembled from GluA1–GluA4
subunits that mediate the majority of fast excitatory synaptic transmission in the brain. In the …
subunits that mediate the majority of fast excitatory synaptic transmission in the brain. In the …
AKAP150 palmitoylation regulates synaptic incorporation of Ca2+-permeable AMPA receptors to control LTP
AM Purkey, KM Woolfrey, KC Crosby, DG Stich… - Cell reports, 2018 - cell.com
Summary Ca 2+-permeable AMPA-type glutamate receptors (CP-AMPARs) containing
GluA1 but lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including …
GluA1 but lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including …
The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning
Z Zhou, A Liu, S Xia, C Leung, J Qi, Y Meng, W Xie… - Nature …, 2018 - nature.com
Long-term potentiation (LTP) and depression (LTD) at glutamatergic synapses are
intensively investigated processes for understanding the synaptic basis for learning and …
intensively investigated processes for understanding the synaptic basis for learning and …
How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD
JW Hell - Science Signaling, 2016 - science.org
Both synaptic long-term potentiation (LTP) and long-term depression (LTD) are thought to be
critical for memory formation. Dell'Acqua and co-workers now demonstrate that transient …
critical for memory formation. Dell'Acqua and co-workers now demonstrate that transient …
Control of homeostatic synaptic plasticity by AKAP-anchored kinase and phosphatase regulation of Ca2+-permeable AMPA receptors
JL Sanderson, JD Scott… - Journal of Neuroscience, 2018 - Soc Neuroscience
Neuronal information processing requires multiple forms of synaptic plasticity mediated by
NMDARs and AMPA-type glutamate receptors (AMPARs). These plasticity mechanisms …
NMDARs and AMPA-type glutamate receptors (AMPARs). These plasticity mechanisms …