Transcriptional response of Aspergillus fumigatus to copper and the role of the Cu chaperones

D Anabosi, Z Meir, Y Shadkchan, M Handelman… - Virulence, 2021 - Taylor & Francis
Aspergillus fumigatus is the leading cause of life-threatening invasive mold infections in
immunocompromised individuals. This ubiquitous saprophyte possesses several natural …

[HTML][HTML] Copper homeostasis in Aspergillus fumigatus: opportunities for therapeutic development

J Song, R Li, J Jiang - Frontiers in microbiology, 2019 - frontiersin.org
Aspergillus fumigatus can cause severe invasive aspergillosis in immunocompromised
individuals. Copper, an essential but potentially toxic trace element for A. fumigatus, plays a …

The Aspergillus fumigatus transcription factor AceA is involved not only in Cu but also in Zn detoxification through regulating transporters CrpA and ZrcA

Z Cai, W Du, Z Zhang, L Guan, Q Zeng… - Cellular …, 2018 - Wiley Online Library
Abstract Copper (Cu) and zinc (Zn) are essential nutrients for both pathogens and hosts;
however, their excess accumulation is toxic for all cells. The Aspergillus transcription factor …

Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis

H Liu, FN Gravelat, LY Chiang, D Chen… - Molecular …, 2010 - Wiley Online Library
Relatively few transcription factors that govern the virulence of Aspergillus fumigatus are
known. We constructed 11 A. fumigatus transcription factor mutants and screened them for …

Divergent Targets of Aspergillus fumigatus AcuK and AcuM Transcription Factors during Growth In Vitro versus Invasive Disease

M Pongpom, H Liu, W Xu, BD Snarr… - Infection and …, 2015 - Am Soc Microbiol
ABSTRACT In Aspergillus nidulans, the AcuK and AcuM transcription factors form a complex
that regulates gluconeogenesis. In Aspergillus fumigatus, AcuM governs gluconeogenesis …

A novel Zn2-Cys6 transcription factor clcA contributes to copper homeostasis in Aspergillus fumigatus

Y Kusuya, C Bian, D Hagiwara, S Ban, H Takahashi - Current Genetics, 2022 - Springer
The filamentous fungus Aspergillus fumigatus is the most important pathogenic fungus
among Aspergillus species associated with aspergillosis. A. fumigatus is exposed to diverse …

Copper Utilization, Regulation, and Acquisition by Aspergillus fumigatus

N Raffa, N Osherov, NP Keller - International Journal of Molecular …, 2019 - mdpi.com
Copper is an essential micronutrient for the opportunistic human pathogen, Aspergillus
fumigatus. Maintaining copper homeostasis is critical for survival and pathogenesis. Copper …

Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus

K Yang, Y Shadkchan, J Tannous… - Virulence, 2018 - Taylor & Francis
The ubiquitous fungus Aspergillus flavus is notorious for contaminating many important
crops and food-stuffs with the carcinogenic mycotoxin, aflatoxin. This fungus is also the …

The Role of Zinc in Copper Homeostasis of Aspergillus fumigatus

S Kang, H Seo, HS Moon, JH Kwon, YS Park… - International journal of …, 2020 - mdpi.com
Copper is an essential metal ion that performs many physiological functions in living
organisms. Deletion of Afmac1, which is a copper-responsive transcriptional activator in A …

Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus

A Yap, M Misslinger, H Haas - Biochemical Journal, 2020 - portlandpress.com
Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening
infection mainly affecting immunocompromised patients. The essential metals copper and …