Copper is an essential metal ion that performs many physiological functions in living
organisms. Deletion of Afmac1, which is a copper-responsive transcriptional activator in A …

Most of the metal transporters in Aspergillus fumigatus are yet uncharacterized. Their role in
fungal metabolism and virulence remains unclear. This paper describes the novel P IB-type …

Although iron and copper are co-ordinately regulated in living cells, the homeostatic effects
of each of these metals on the other remain unknown. Here, we show the function of AfMac1 …

The Fenton-chemistry-generating properties of copper ions are considered a potent
phagolysosome defense against pathogenic microbes, yet our understanding of underlying …

The Fenton-chemistry generating properties of copper ions are considered a potent
phagolysosome defense against pathogenic microbes, yet our understanding of underlying …

Although copper functions as a cofactor in many physiological processes, copper overload
leads to harmful effects in living cells. Thus, copper homeostasis is tightly regulated …

Copper (Cu) is an essential trace element and is regarded as an important virulence factor
in fungal pathogens. Previous studies suggest that a putative Cu-sensing transcription factor …

Background Aspergillus fumigatus has to cope with a combination of several stress types
while colonizing the human body. A functional interplay between these different stress …

Copper (Cu) is an essential metal for all living organisms, although it is toxic in excess.
Filamentous fungus must acquire copper from its environment for growth. Despite its …

The transition metals iron and copper are required by virtually all organisms but are toxic in
excess. Acquisition of both metals and resistance to copper excess have previously been …