Copper (Cu) is an essential metal that is toxic at high concentrations. Thus, pathogens often
rely on host Cu for growth, but host cells can hyperaccumulate Cu to exert antimicrobial …

Aspergillus fumigatus is an important fungal pathogen that causes allergic reactions but also
life-threatening infections. One of the most abundant A. fumigatus proteins is Asp f3. This …

Macrophages and neutrophils kill the airborne fungal pathogen Aspergillus fumigatus. The
dependency of this killing process on reactive oxygen intermediates (ROI) has been strongly …

Candida species and Aspergillus fumigatus were once thought to be relatively benign
organisms. However, it is now known that this is not the case? Candida species rank among …

Fungal pathogens have evolved sophisticated machinery to precisely balance the fine line
between acquiring essential metals and defending against metal toxicity. Iron and copper …

This chapter is a compilation of the current knowledge about Aspergillus fumigatus
mechanisms involved in maintaining iron (Fe) and zinc (Zn) homeostasis and their impact on …

Zinc plays a critical role in a diverse array of biochemical processes. However, excess of
zinc is deleterious to cells. Therefore, cells require finely tuned homeostatic mechanisms to …

Background Aspergillus fumigatus is a human fungal pathogen that causes aspergillosis in
immunocompromised hosts. A. fumigatus is believed to be exposed to diverse …

Intracellular pathogens residing within macrophage phagosomes are challenged with
recognizing the phagosomal environment and appropriately responding to changing host …

Aspergillus fumigatus is the most prevalent airborne filamentous fungal pathogen in
humans, causing severe and often fatal invasive infections in immunocompromised patients …