The small GTPase RhoA and its downstream effector, Rho kinase (ROCK), appear to
mediate numerous pathophysiological signals, including smooth muscle cell contraction …

The worldwide epidemic scale of diabetes mellitus has been underestimated for a long time.
Currently every 10 seconds one patient dies of diabetes-related pathologies. Given the high …

Rho-kinase (ROCK) is one of the downstream effectors of the small G-protein Rho. The Rho–
ROCK pathway has an important role in mediating various cellular functions, including …

RhoA and Rho-kinase (ROCK) participate in diverse cellular signaling functions such as
smooth muscle contraction, cytoskeleton rearrangement, and cell migration and …

Despite remaining questions in this field, such as the specificity of currently available
ROCKi, or the roles of individual ROCK isoforms, recent evidence in experimental diabetes …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and is
strongly associated with cardiovascular mortality. Given the pandemic of obesity and …

The emerging critical implications of Rho/Rho-kinase (ROCK) signaling in
neurodegenerative diseases, glaucoma, renoprotection, diabetes and cancer have sparked …

Rho kinase (ROCK) belongs to a family of Ser/Thr protein kinases that are activated via
interaction with the small GTP-binding protein RhoA. Growing evidence suggests that RhoA …

The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as
downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various …

RhoA/Rho kinase: a novel therapeutic target in diabetic comp... : Chinese Medical Journal
RhoA/Rho kinase: a novel therapeutic target in diabetic complications : Chinese Medical Journal …