Neutrophils are critical for mediating inflammatory responses. Inhibiting neutrophil
recruitment is an attractive approach for preventing inflammatory injuries, including …

Background—We investigated the effect of epidermal growth factor–like domain 7 (Egfl7) on
nuclear factor-κB activation, intercellular adhesion molecule-1 expression, and neutrophil …

Neutrophil migration requires β 2 integrins and chemoattractant receptor signaling for
motility and directionality. G protein subunit Gα 13 can facilitate cell migration by mediating …

We studied the basis of inhibition of polymorphonuclear leukocyte (PMN) adhesion induced
by neutrophil inhibitory factor (NIF), a 41-kDa CD11/CD18 β2 integrin-binding protein …

Reperfusion of ischemic myocardium is necessary to salvage tissue from eventual death.
However, reperfusion after even brief periods of ischemia is associated with pathologic …

We reported the expression of angiopoietin Tie2 receptor on human neutrophils and the
capacity of angiopoietins (Ang1 and Ang2) to induce pro-inflammatory activities, such as …

Strong evidence suggests that neutrophils may play an active role in acute and chronic
inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. Given the role of …

Inflammation is a crucial factor in cardiac remodeling after acute myocardial infarction (MI).
Neutrophils, as the first wave of leukocytes to infiltrate the injured myocardium, exacerbate …

Neutrophils constitute the first line of cellular defense in response to bacterial and fungal
infections and rely on granular proteins to kill microorganisms, but uncontrolled secretion of …

Integrin-mediated migration of neutrophils to infected tissue sites is vital for pathogen
clearance and therefore host survival. Although β2 integrins have been shown to mediate …