Over the last decade, research in somatic gene therapy has focused on selected
approaches to deliver therapeutic genes to cells both ex vivo and in vivo. While most current …

The use of nonviral plasmid-based gene medicines represents an attractive in vivo gene
transfer strategy that is simple and lacks many risks that are inherent to viral systems …

Recent advances in molecular biology combined with the culmination of the Human
Genome Project [1] have provided a genetic understanding of cellular processes and …

Although most research on gene therapy has focused on the development of viral-mediated
approaches to deliver therapeutic genes to cells both ex vivo and in vivo, non-viral gene …

Gene therapy requires the introduction of genetic material in diseased cells with the aim of
treating or ultimately curing a disease. Since the start of gene therapy clinical trials in 1990 …

First-generation gene medicines and genetic vaccines represent a promising new class of
therapeutics that have the potential to prevent, correct, or modulate genetic or acquired …

Non-viral gene therapies are currently under development that employ drug-delivery
methods for targeting genes to selected cells in the body, where they express therapeutic …

Gene therapy is a medical/surgical intervention currently being developed, in which genes
are introduced into cells in order to treat or cure a wide variety of human diseases. The field …

Thanks to the changes in medicine, pharmacological treatment rapidly progresses into new
fields. There is an emphasis on the development of treatment methods to eliminate …

▪ Abstract Broadly defined, the concept of gene therapy involves the transfer of genetic
material into a cell, tissue, or whole organ, with the goal of curing a disease or at least …