Insulin plays a range of roles as an anabolic hormone in peripheral tissues. It regulates
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …

Introduction• Insulin, IGF‐1 in the brain• Glucose metabolism and AD• The insulin and IGF‐1
system in AD• The insulin and oxidative stress in AD• The insulin and IGF‐1R system and τ …

In the last two decades, numerous in vitro studies demonstrated that insulin receptors and
theirs downstream pathways are widely distributed throughout the brain. This evidence has …

Alzheimer's disease (AD) is the main type of dementia and is a disease with a profound
socioeconomic burden due to the lack of effective treatment. In addition to genetics and …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Its major
pathological hallmarks, neurofibrillary tangles (NFT), and amyloid-β plaques can result from …

Hyperinsulinemia as well as type II diabetes mellitus are among the risk factors for
Alzheimer's disease (AD). However, the molecular and cellular basis that link insulin …

Alzheimer's disease, a progressive neurodegenerative disorder, is one of the leading
causes of death in the USA, along with cancer and cardiac disorders. AD is characterized by …

The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly
with the aging of the population. Numerous epidemiological data suggest that there is a …

Recent studies continue to find evidence linking Type 2 diabetes (T2D) with Alzheimer's
disease (AD), the most common cause of dementia, a general term for memory loss and …

Insulin plays a major neuroprotective and trophic function for cerebral cell population, thus
countering apoptosis, beta-amyloid toxicity, and oxidative stress; favoring neuronal survival; …