Cryptococcus neoformans is a facultative intracellular pathogen and its interaction with
macrophages is a key event determining the outcome of infection. Urease is a major …

Ureases (EC 3.5. 1.5) are Ni2+‐dependent metalloenzymes produced by plants, fungi and
bacteria that hydrolyze urea to produce ammonia and CO2. The insertion of nickel atoms …

Urease, a major virulence factor for Cryptococcus neoformans, promotes lethal meningitis/
encephalitis in mice. The effect of urease within the lung, the primary site of most invasive …

Urease in Cryptococcus neoformans plays an important role in fungal dissemination to the
brain and causing meningoencephalitis. Although urea is not required for synthesis of …

The fungus Cryptococcus neoformans is the causative agent of cryptococcosis, a disease
that is uniformly lethal unless treated with antifungal drugs, yet current regimens are …

Cryptococcus neoformans is a fungal pathogen with worldwide distribution. C. neoformans
resides within mature phagolysosomes where it often evades killing and replicates. C …

Our objective was to determine the role of the cryptococcal virulence factor urease in
pulmonary-to-central nervous system, dissemination, invasion, and growth. C. neoformans …

Upon ingestion by macrophages, Cryptococcus neoformans can survive and replicate
intracellularly unless the macrophages become classically activated. The mechanism …

Degradation of purines to uric acid is generally conserved among organisms, however, the
end product of uric acid degradation varies from species to species depending on the …

Urease catalyzes the hydrolysis of urea to ammonia and carbamate and has been found to
be an important pathogenic factor for certain bacteria. Cryptococcus neoformans is a …