The Anti-Angiogenic Effect of Atorvastatin Loaded Exosomes on Glioblastoma Tumor Cells: An in Vitro 3D Culture Model

FE Ranjbar, ZV Malekshahi, N Mokhberian… - papers.ssrn.com
AbstractExosomes (EXOs) are natural lipid bilayers nano-structures that can be utilized as
nano-delivery systems to deliver various types of drugs and genetic materials to target cells …

The anti-angiogenic effect of atorvastatin loaded exosomes on glioblastoma tumor cells: An in vitro 3D culture model

E Valipour, FE Ranjbar, M Mousavi, J Ai… - Microvascular …, 2022 - Elsevier
Exosomes are endogenous nanoparticles with a lipid bilayer membrane whose natural
function as carriers of biological materials has attracted much attention. The ability of …

[HTML][HTML] Impact of atorvastatin loaded exosome as an anti-glioblastoma carrier to induce apoptosis of U87 cancer cells in 3D culture model

VT Nooshabadi, M Khanmohammadi, S Shafei… - … and biophysics reports, 2020 - Elsevier
Exosomes (EXOs) are naturally occurring nanosized lipid bilayers that can be efficiently
used as a drug delivery system to carry small pharmaceutical, biological molecules and …

Isolation and identification of adipose stem cell exosomes and the study of its potential as drug delivery carrier in vitro

X Zhang, C Han, B Du, D Nan, W Zhang… - Applied Biochemistry and …, 2022 - Springer
Most small molecule anticancer drugs have high lipophilicity and low water solubility, which
is often regarded as a key obstacle to their development and clinical applications. A variety …

In Vitro Blood–Brain Barrier Permeability and Cytotoxicity of an Atorvastatin-Loaded Nanoformulation Against Glioblastoma in 2D and 3D Models

MM Lübtow, S Oerter, S Quader… - Molecular …, 2020 - ACS Publications
Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase of the family of
statins have been suggested as therapeutic options in various tumors. Atorvastatin is a statin …

Asiatic acid encapsulated exosomes of hepatocellular carcinoma inhibit epithelial-mesenchymal transition through transforming growth factor beta/smad signaling …

T Chen, C Zhu, X Wang, Y Pan… - Journal of Biomedical …, 2021 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death in
many countries, which accounts for more than 80% of primary liver cancers. Better …

Exosomes Derived from Gold Nanorod Engineered Vascular Endothelial Cells Inhibit Tumor Growth via Disrupting the TGFβ Pathway

W Zhu, R Zhang, Z Zhao, N Zhao, X Gui… - Journal of …, 2022 - Wiley Online Library
Exosomes are nanosized extracellular vesicles which are emerging as novel therapeutic
nanoparticles. This paper reports a novel concept of engineering exosomes using …

Apoptotic effect of atorvastatin in glioblastoma spheroids tumor cultured in fibrin gel

N Bayat, S Ebrahimi-Barough… - Biomedicine & …, 2016 - Elsevier
Objective Glioblastoma multiform (GBM) is one of the most common and highly aggressive
primary brain tumors that thought to be of glial cells origin. The new available therapy for …

Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle

H Gomari, M Forouzandeh Moghadam… - OncoTargets and …, 2018 - Taylor & Francis
Purpose Exosomes are small 30–100 nm vesicles secreted by various cell types. They are
released by most cell types, indicating their important role in physiological and pathological …

[HTML][HTML] Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications

M Ahmadi, J Rezaie - Journal of translational medicine, 2020 - Springer
Angiogenesis is a multistep process and various molecules are involved in regulating it.
Extracellular vesicles are cell-derived particles, secreted from several types of cells and are …