Filamentous fungi can produce many valuable secondary metabolites; among these fungi,
endophytic fungi play an ecological role in mutualistic symbiosis with plants, including …

Trichoderma reesei has been explored intensively in the laboratory and on an industrial
scale for its highly potent cellulase secretion machinery since its characterization over 70 …

Bacteria of the order Actinomycetales are one of the most important sources of
pharmacologically active and industrially relevant secondary metabolites. Unfortunately …

Phytopathogenic bacteria play important roles in plant productivity, and developments in
gene editing have potential for enhancing the genetic tools for the identification of critical …

The filamentous fungus Fusarium fujikuroi is well-known for its production of natural plant
growth hormones: a series of gibberellic acids (GAs). Some GAs, including GA1, GA3, GA4 …

A highly efficient genome editing system for Bacillus licheniformis was developed based on
single-plasmid CRISPR/Cas9. For highly efficient genome editing the shuttle vector …

The CRISPR/Cas9 system has been successfully applied for gene editing in filamentous
fungi. Previous studies reported that single stranded oligonucleotides can be used as repair …

Aspergillus niger and other filamentous fungi are widely used in industry, but efficient
genetic engineering of these hosts remains nascent. For example, while molecular genetic …

CRISPR-Cas mediated genome engineering has revolutionized functional genomics.
However, understanding of DNA repair following Cas-mediated DNA cleavage remains …

Genome editing technology has rapidly evolved to knock-out genes, create targeted genetic
variation, install precise insertion/deletion and single nucleotide changes, and perform large …