Population pharmacokinetics of continuous infusion of piperacillin/tazobactam in very elderly hospitalized patients and considerations for target attainment against …
Continuous infusion (CI) piperacillin/tazobactam is frequently used to treat infections in very
elderly patients. This study aimed to conduct a population pharmacokinetic analysis of CI …
elderly patients. This study aimed to conduct a population pharmacokinetic analysis of CI …
Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with nosocomial infections
R Chen, Q Qian, M Sun, C Qian, S Zou, M Wang… - European journal of …, 2016 - Springer
Objective The study was to establish a population pharmacokinetic (PPK) model of
piperacillin (PIP) and tazobactam (TAZ) that explain pharmacokinetic variability and to …
piperacillin (PIP) and tazobactam (TAZ) that explain pharmacokinetic variability and to …
[HTML][HTML] Population pharmacokinetic modeling and pharmacodynamic target attainment simulation of piperacillin/tazobactam for dosing optimization in late elderly …
N Ishihara, N Nishimura, K Ikawa, F Karino, K Miura… - Antibiotics, 2020 - mdpi.com
The aim of this study was to develop a population pharmacokinetic model for piperacillin
(PIPC)/tazobactam (TAZ) in late elderly patients with pneumonia and to optimize the …
(PIPC)/tazobactam (TAZ) in late elderly patients with pneumonia and to optimize the …
Population pharmacokinetics of piperacillin/tazobactam across the adult lifespan
M Hemmersbach-Miller, SJ Balevic, PL Winokur… - Clinical …, 2023 - Springer
Abstract Background and Objective Piperacillin/tazobactam is one of the most frequently
used antimicrobials in older adults. Using an opportunistic study design, we evaluated the …
used antimicrobials in older adults. Using an opportunistic study design, we evaluated the …
Population pharmacokinetics of piperacillin following continuous infusion in critically ill patients and impact of renal function on target attainment
V Klastrup, A Thorsted, M Storgaard… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Pharmacokinetic changes are often seen in patients with severe infections. Administration
by continuous infusion has been suggested to optimize antibiotic exposure and …
by continuous infusion has been suggested to optimize antibiotic exposure and …
Steady-state pharmacokinetics and pharmacodynamics of piperacillin/tazobactam administered by prolonged infusion in hospitalised patients
KM Shea, SC Cheatham, MF Wack, DW Smith… - International journal of …, 2009 - Elsevier
The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …
Pharmacokinetics and pharmacodynamics of piperacillin/tazobactam when administered by continuous infusion and intermittent dosing
DS Burgess, T Waldrep - Clinical therapeutics, 2002 - Elsevier
Background: Although intermittent bolus dosing is currently the standard of practice for many
antimicrobial agents, beta-lactams exhibit time-dependent bacterial killing. Maximizing the …
antimicrobial agents, beta-lactams exhibit time-dependent bacterial killing. Maximizing the …
Population pharmacokinetics of extended-infusion piperacillin-tazobactam in hospitalized patients with nosocomial infections
While extended infusions of piperacillin-tazobactam (TZP) are increasingly used in practice,
the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely …
the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely …
Comparative pharmacodynamics of intermittent and prolonged infusions of piperacillin/tazobactam using Monte Carlo simulations and steady-state pharmacokinetic …
KM Shea, SC Cheatham, DW Smith… - Annals of …, 2009 - journals.sagepub.com
Background: Prolonging the infusion of a β-lactam antibiotic enhances the time in which
unbound drug concentrations remain above the minimum inhibitory concentration (fT> MIC) …
unbound drug concentrations remain above the minimum inhibitory concentration (fT> MIC) …
Pharmacodynamic profiling of piperacillin in the presence of tazobactam in patients through the use of population pharmacokinetic models and Monte Carlo …
TP Lodise Jr, B Lomaestro, KA Rodvold… - Antimicrobial agents …, 2004 - Am Soc Microbiol
The primary objectives of this analysis were to determine which pharmacokinetic model
most accurately describes the elimination pathways for piperacillin in the presence of …
most accurately describes the elimination pathways for piperacillin in the presence of …