Continuous infusion (CI) piperacillin/tazobactam is frequently used to treat infections in very
elderly patients. This study aimed to conduct a population pharmacokinetic analysis of CI …

Objective The study was to establish a population pharmacokinetic (PPK) model of
piperacillin (PIP) and tazobactam (TAZ) that explain pharmacokinetic variability and to …

Abstract Background and Objective Piperacillin/tazobactam is one of the most frequently
used antimicrobials in older adults. Using an opportunistic study design, we evaluated the …

The aim of this study was to develop a population pharmacokinetic model for piperacillin
(PIPC)/tazobactam (TAZ) in late elderly patients with pneumonia and to optimize the …

Pharmacokinetic changes are often seen in patients with severe infections. Administration
by continuous infusion has been suggested to optimize antibiotic exposure and …

Background: Although intermittent bolus dosing is currently the standard of practice for many
antimicrobial agents, beta-lactams exhibit time-dependent bacterial killing. Maximizing the …

The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …

While extended infusions of piperacillin-tazobactam (TZP) are increasingly used in practice,
the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely …

Background: Prolonging the infusion of a β-lactam antibiotic enhances the time in which
unbound drug concentrations remain above the minimum inhibitory concentration (fT> MIC) …

The primary objectives of this analysis were to determine which pharmacokinetic model
most accurately describes the elimination pathways for piperacillin in the presence of …