Sudden myocardial ischaemia causes an acute coronary syndrome. In the case of ST-
elevation myocardial infarction (STEMI), this is usually caused by the acute rupture of …

Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Animal models of sustained ischemia have shown exacerbation of myocardial injury during
reperfusion, mediated largely by cytotoxic effects of free radical generation, complement …

Acute myocardial infarction is caused by coronary occlusion, and the mainstay of treatment
has become reperfusion by either coronary angioplasty with possible stenting or surgical …

The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

While progress has been made in improving survival following myocardial infarction, this
injury remains a major source of mortality and morbidity despite modern reperfusion therapy …

One explanation for the failure to translate cardioprotection into clinical practice is that RI
does not occur in humans. However, it would be unusual for a biological phenomenon to be …

Myocardial infarct size is a major determinant of prognosis. Ischaemic preconditioning with
brief coronary occlusion and reperfusion before a sustained period of coronary occlusion …

For almost 30 years, urgent revascularization termed primary percutaneous coronary
intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It …

The main determinant of myocardial necrosis following an acute myocardial infarction (AMI)
is duration of ischemia. Infarct size is a strong independent predictor of postinfarction …