Introduction: The recreational use of fentanyl in combination with xylazine (ie,“tranq-dope”)
represents a rapidly emerging public health threat characterized by significant toxicity and …

Background Fentanyl is commonly laced with xylazine. People who use this combination
report heightened effects, but it also increases death risk. Although no medication has been …

Introduction Non-pharmaceutical fentanyl and its analogs have driven striking increases in
opioid-associated overdose deaths. These highly potent opioids can be found at low …

In the 1960s, Bayer 1470, an alpha2-adrenergic agonist similar to clonidine, was
investigated as an antihypertensive in humans, only to be abandoned because it produced …

Opiates and substitution products are frequently abused, alone and in association with
benzodiazepines. While this combination may result in severe respiratory depression and …

Background Fentanyl has replaced most other non-prescribed opioids in much of North
America. There is controversy over whether a hypothetical reduced efficacy of naloxone in …

Reports from active drug users state that xylazine, the veterinary tranquilliser, has been
increasing in the illicit drug supply in Philadelphia. To describe trends and characteristics of …

Prescription and illicit opioid use are a public health crisis, with the landscape shifting to
fentanyl use. Since fentanyl is 100-fold more potent than morphine, its use is associated with …

Abstract Purpose of Review The opioid epidemic has been responsible for significant
morbidity and mortality in the USA and worldwide. As a result, it is essential to recognize the …

Changes in the drug supply landscape directly influence morbidity and mortality with the
reduced efficacy of naloxone to reverse fentanyl overdose (versus heroin) emphasizing this …