Introduction Paediatric clinical practice for treatment of venous thromboembolism (VTE) is
based on extrapolation from adult trials with minimal data on anticoagulation efficacy and …

Background Venous thromboembolism (VTE) is a relatively rare condition in childhood with
treatment mainly based on extrapolation from studies in adults. Therefore, clinical trials of …

The incidence of venous thromboembolism (VTE) in the pediatric population has increased
more than 10-fold in the last 20 years, as a consequence of the advancement of …

Introduction Anticoagulant therapy is in use for both prevention and treatment of venous and
arterial thromboembolic disorders. Delivering safe and effective anticoagulation in the …

Background Treatment of venous thromboembolism in children is based on data obtained in
adults with little direct documentation of its efficacy and safety in children. The aim of our …

Background Recently, the randomized EINSTEIN‐Jr study showed similar efficacy and
safety for rivaroxaban and standard anticoagulation for treatment of pediatric venous …

Background Rivaroxaban has been shown to be efficacious for treatment of venous
thromboembolism in adults, and has a reduced risk of bleeding compared with standard …

Background: Treatment of venous thromboembolism (VTE) in children is based on data
obtained in adults with little direct documentation of its efficacy and safety in children …

Background: Venous thromboembolism (VTE) in children occurs with increasing frequency
predominantly as a result of hospital-acquired thrombosis leading to a substantial rise in the …

Abstract Background The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment
of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg …