[HTML][HTML] Transcriptome-wide m6A methylome during osteogenic differentiation of human adipose-derived stem cells
Objectives Adipose-derived stem cells are frequently used for bone regeneration both in
vitro and in vivo. N 6-methyladenosine (m 6 A) is the most abundant post-transcriptional …
vitro and in vivo. N 6-methyladenosine (m 6 A) is the most abundant post-transcriptional …
[HTML][HTML] N6-Methyladenosine in Cell-Fate Determination of BMSCs: From Mechanism to Applications
Q Zhang, J Li, C Wang, Z Li, P Luo, F Gao, W Sun - Research, 2024 - spj.science.org
The methylation of adenosine base at the nitrogen-6 position is referred to as “N6-
methyladenosine (m6A)” and is one of the most prevalent epigenetic modifications in …
methyladenosine (m6A)” and is one of the most prevalent epigenetic modifications in …
[HTML][HTML] Mettl3 regulates osteogenic differentiation and alternative splicing of Vegfa in bone marrow mesenchymal stem cells
C Tian, Y Huang, Q Li, Z Feng, Q Xu - International Journal of Molecular …, 2019 - mdpi.com
Bone mesenchymal stem cells (BMSCs) can be a useful cell resource for developing
biological treatment strategies for bone repair and regeneration, and their therapeutic …
biological treatment strategies for bone repair and regeneration, and their therapeutic …
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG
L Chen, M Zhang, P Chen, X Xiong, P Liu… - Acta Pharmacologica …, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is the most abundant posttranscriptional methylation
modification that occurs in mRNA and modulates the fine-tuning of various biological …
modification that occurs in mRNA and modulates the fine-tuning of various biological …
Emerging role of m6A modification in osteogenesis of stem cells
Z Zou, T He, Y Liu, L Zheng, Y Zhong, Y Mo… - Journal of Bone and …, 2022 - Springer
The differentiation of stem cells into osteoblasts is a key link in the treatment of bone defects
and other orthopedic diseases. N6-methyladenosine (m6A) modification, an important post …
and other orthopedic diseases. N6-methyladenosine (m6A) modification, an important post …
[HTML][HTML] The N6-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6
Z Li, P Wang, J Li, Z Xie, S Cen, M Li, W Liu, G Ye… - Cell Death & …, 2021 - nature.com
Abstract N 6-methyladenosine (m6A) modification is widespread in messenger RNAs and
increasing evidence suggests the crucial roles of m6A in cell differentiation and tissue …
increasing evidence suggests the crucial roles of m6A in cell differentiation and tissue …
[HTML][HTML] Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
Y Wu, L Xie, M Wang, Q Xiong, Y Guo, Y Liang… - Nature …, 2018 - nature.com
Abstract N6-methyladenosine (m6A) is the most abundant epigenetic modification in
eukaryotic mRNAs and is essential for multiple RNA processing events during mammalian …
eukaryotic mRNAs and is essential for multiple RNA processing events during mammalian …
WTAP-mediated m6A RNA methylation regulates the differentiation of bone marrow mesenchymal stem cells via the miR-29b-3p/HDAC4 axis
J Liu, Y You, Z Sun, L Zhang, X Li, Z Dai… - Stem Cells …, 2023 - academic.oup.com
Abstract N6-methyladenosine (m6A) methylation, a well-known modification with new
epigenetic functions, has been reported to participate in the progression of osteoporosis …
epigenetic functions, has been reported to participate in the progression of osteoporosis …
The m6A Reader YTHDF1 Accelerates the Osteogenesis of Bone Marrow Mesenchymal Stem Cells Partly via Activation of the Autophagy Signaling Pathway
X Gao, J Wang, Y Wang, W Li, Z Pan - Stem Cells International, 2023 - Wiley Online Library
N6‐methyladenosine (m6A) mRNA methylation has emerged as an important player in
many biological processes by regulating gene expression. As a crucial reader, YTHDF1 …
many biological processes by regulating gene expression. As a crucial reader, YTHDF1 …
[HTML][HTML] Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis
X Chen, W Hua, X Huang, Y Chen, J Zhang… - Frontiers in …, 2020 - frontiersin.org
Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone
structure is destroyed to the degree that bone becomes fragile and prone to fractures …
structure is destroyed to the degree that bone becomes fragile and prone to fractures …