New insights into the regulatory roles of extracellular vesicles in tumor angiogenesis and their clinical implications

M Huang, Y Lei, Y Zhong, C Chung, M Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
Angiogenesis is required for tumor growth and development. Extracellular vesicles (EVs) are
important signaling entities that mediate communication between diverse types of cells and …

Noncoding RNAs of extracellular vesicles in tumor angiogenesis: from biological functions to clinical significance

M Hu, J Li, CG Liu, RMWJ Goh, F Yu, Z Ma, L Wang - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) act as multifunctional regulators of intercellular communication
and are involved in diverse tumor phenotypes, including tumor angiogenesis, which is a …

Extracellular vesicle‐mediated regulation of tumor angiogenesis—implications for anti‐angiogenesis therapy

S Zhang, J Yang, L Shen - Journal of Cellular and Molecular …, 2021 - Wiley Online Library
Angiogenesis plays an important role in tumour progression. However, anti‐angiogenesis
therapy of inhibiting pro‐angiogenic factors failed to meet expectations in certain types of …

[HTML][HTML] Tumor-derived extracellular vesicles in angiogenesis

W Song, D Yan, T Wei, Q Liu, X Zhou, J Liu - Biomedicine & …, 2018 - Elsevier
Angiogenesis is crucial for tumor growth and metastasis. Recent studies revealed that tumor
cells promote angiogenesis by secreting extracellular vesicles, which can be captured by …

Distinct mRNAs in Cancer Extracellular Vesicles Activate Angiogenesis and Alter Transcriptome of Vascular Endothelial Cells

P Zhang, SB Lim, K Jiang, TW Chew, BC Low, CT Lim - Cancers, 2021 - mdpi.com
Simple Summary Cancer extracellular vesicles (EVs) are implicated in various processes of
cancer development, with most of the EV-induced changes attributed to EV proteins and …

Extracellular vesicles as central regulators of blood vessel function in cancer

FG Kugeratski, A Santi, S Zanivan - Science signaling, 2022 - science.org
Blood vessels deliver oxygen and nutrients that sustain tumor growth and enable the
dissemination of cancer cells to distant sites and the recruitment of intratumoral immune …

Message in a bottle: Endothelial cell regulation by extracellular vesicles

C Palazzo, A D'Alessio, L Tamagnone - Cancers, 2022 - mdpi.com
Simple Summary Elucidating the role of extracellular vesicles (EVs) in the communication
mechanisms between cancer and endothelial cells (ECs) within the tumor microenvironment …

Non-coding RNAs of extracellular vesicles: Key players in organ-specific metastasis and clinical implications

Q Jiang, XP Tan, CH Zhang, ZY Li, D Li, Y Xu, YX Liu… - Cancers, 2022 - mdpi.com
Simple Summary Metastasis refers to the progressive dissemination of primary tumor cells
and their colonization of other tissues, and is a major cause of treatment failure in cancer …

Extracellular vesicles: important collaborators in cancer progression

S Sato, AM Weaver - Essays in biochemistry, 2018 - portlandpress.com
Extracellular vesicles (EVs) are membrane vesicles that are released from cells and mediate
cell–cell communication. EVs carry protein, lipid, and nucleic acid cargoes that interact with …

Extracellular vesicles are key regulators of tumor neovasculature

N Kuriyama, Y Yoshioka, S Kikuchi… - Frontiers in Cell and …, 2020 - frontiersin.org
Tumor progression involves a series of biologically important steps in which the crosstalk
between cancer cells and the surrounding environment is an important issue. Angiogenesis …