Enhanced penetration of pro-apoptotic and anti-angiogenic micellar nanoprobe in 3D multicellular spheroids for chemophototherapy

A Mozhi, V Sunil, W Zhan, PB Ghode, NV Thakor… - Journal of Controlled …, 2020 - Elsevier
Light irradiation is considered an ideal non-invasive stimulus that enables precise tumour
treatment with flexible, facile, and spatiotemporal control. Photodynamic therapy (PDT) is an …

Photodynamic nanomedicine in the treatment of solid tumors: perspectives and challenges

A Master, M Livingston, AS Gupta - Journal of controlled release, 2013 - Elsevier
Photodynamic therapy (PDT) is a promising treatment strategy where activation of
photosensitizer drugs with specific wavelengths of light results in energy transfer cascades …

Expanding the limits of photodynamic therapy: the design of organelles and hypoxia-targeting nanomaterials for enhanced photokilling of cancer

IR Calori, H Bi, AC Tedesco - ACS Applied Bio Materials, 2021 - ACS Publications
Photodynamic therapy (PDT) is a minimally invasive clinical protocol that combines a
nontoxic photosensitizer (PS), appropriate visible light, and molecular oxygen for cancer …

Engineering nanoparticles for optimized photodynamic therapy

X Dai, T Du, K Han - ACS Biomaterials Science & Engineering, 2019 - ACS Publications
Photodynamic therapy as a local therapeutic method shows great biocompatibility in tumor
therapy. However, the poor accumulation of photosensitizer in tumors restricted the …

[HTML][HTML] Combinatorial therapeutic approaches with nanomaterial-based photodynamic cancer therapy

Y Hao, CK Chung, Z Yu, RV Huis in 't Veld… - Pharmaceutics, 2022 - mdpi.com
Photodynamic therapy (PDT), in which a light source is used in combination with a
photosensitizer to induce local cell death, has shown great promise in therapeutically …

[HTML][HTML] High-throughput cancer cell sphere formation for characterizing the efficacy of photo dynamic therapy in 3D cell cultures

YC Chen, X Lou, Z Zhang, P Ingram, E Yoon - Scientific reports, 2015 - nature.com
Photodynamic therapy (PDT), wherein light sensitive non-toxic agents are locally and
selectively activated using light, has emerged as an appealing alternative to traditional …

Tumor microenvironment-regulated and reported nanoparticles for overcoming the self-confinement of multiple photodynamic therapy

C Li, X Zheng, W Chen, S Ji, Y Yuan, X Jiang - Nano Letters, 2020 - ACS Publications
The efficiency of photodynamic therapy (PDT) highly depends on the tumor oxygenation
state. However, PDT itself can not only cause oxygen depletion but also prevent oxygen …

Hybrid nanospheres to overcome hypoxia and intrinsic oxidative resistance for enhanced photodynamic therapy

L Shi, F Hu, Y Duan, W Wu, J Dong, X Meng, X Zhu… - ACS …, 2020 - ACS Publications
Photodynamic therapy (PDT) has been a well-accepted clinical treatment for malignant
tumors owing to its noninvasiveness and high spatiotemporal selectivity. However, the …

Dual-step irradiation strategy to sequentially destroy singlet oxygen-responsive polymeric micelles and boost photodynamic cancer therapy

K Deng, H Yu, JM Li, KH Li, HY Zhao, M Ke, SW Huang - Biomaterials, 2021 - Elsevier
Nanotechnology provides a powerful tool to overcome many disadvantages of small-
molecule photosensitizers for photodynamic cancer therapy, such as hydrophobicity, rapid …

Supramolecular micelles as multifunctional theranostic agents for synergistic photodynamic therapy and hypoxia-activated chemotherapy

X Huang, T Chen, N Mu, HW Lam, C Sun, L Yue… - Acta biomaterialia, 2021 - Elsevier
Photodynamic therapy (PDT), where a photosensitizer (under light irradiation) converts
molecular oxygen to singlet oxygen to elicit programmed cell death, is a promising cancer …