The emergence of high-level tigecycline resistance mediated by plasmid-borne tet (X) genes
greatly threatens the clinical effectiveness of tigecycline. However, the dissemination pattern …

The recent emergence of plasmid-mediated tigecycline resistance gene tet (X) has
challenged the clinical effectiveness of tigecycline as a last-resort treatment option. During …

Objectives The aim of this study was to characterise a novel tet (X6)-carrying plasmid
detected in a livestock-associated Acinetobacter towneri isolate. Methods PCR screening …

The emergence of plasmid-mediated tigecycline resistance genes has attracted a great deal
of attention globally. Currently, no comprehensive in-depth genomic epidemiology study of …

Tigecycline is the antibiotic of last resort for the treatment of extensively drug-resistant
bacterial infections, mainly those of multidrug-resistant Gram-negative bacteria. The plasmid …

Objectives Tetracyclines are used in veterinary medicine for livestock. Tigecycline, a
semisynthetic tetracycline derivative, is a last-resort antimicrobial used to treat multidrug …

Public health interventions to control the recent emergence of plasmid-mediated tigecycline
resistance genes rely on a comprehensive understanding of its epidemiology and …

The emergence of the plasmid-mediated high levels of the tigecycline resistance gene has
drawn worldwide attention and has posed a major threat to public health. In this study, we …

Emergence of high-level tigecycline resistance tet (X) variants in animal and human
Enterobacterales is posing a public health concern. Recently, novel tet (X) variants including …

Tigecycline serves as one of the antibiotics of last resort to treat multidrug-resistant
(including carbapenem-resistant) pathogens. However, the recently emerged plasmid …