Computed tomography (CT) and spirometry are the mainstays of clinical pulmonary
assessment. Spirometry is effort dependent and only provides a single global measure that …

Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function
and may be characteristic of early pulmonary disease. While standard indices like …

The mouse is now the primary animal used to model a variety of lung diseases. To study the
mechanisms that underlie such pathologies, phenotypic methods are needed that can …

During breathing, lung inflation is a dynamic process involving a balance of mechanical
factors, including trans-pulmonary pressure gradients, tissue compliance and airway …

Within pulmonary research, the development of mouse models has provided insight into
disease development, progression, and treatment. Structural phenotypes of the lung in …

The use of traditional pulmonary function tests (PFT) to assess airflow obstruction is limited
by the fact that these measurements are global and can neither express the potential …

In vivo lung micro-computed tomography (micro-CT) is being increasingly embraced in
pulmonary research because it provides longitudinal information on dynamic disease …

Pulmonary function analysis is an important tool in the evaluation of mouse respiratory
disease models, but much controversy still exists on the validity of some tests. Most …

Experimental in-vivo animal models are key tools to investigate the pathogenesis of lung
disease and to discover new therapeutics. Histopathological and biochemical investigations …

Lung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-
threatening conditions that slowly deteriorate quality of life and for which our diagnostic …