Nonshivering thermogenesis occurs in brown adipose tissue to generate heat in response to
cold ambient temperatures. Thioesterase superfamily member 1 (Them1) is transcriptionally …

Hepatic insulin resistance in the setting of steatosis is attributable at least in part to the
accumulation of bioactive lipids that suppress insulin signaling. The mitochondria …

The incorporation of excess saturated free fatty acids (SFAs) into membrane phospholipids
within the ER promotes ER stress, insulin resistance, and hepatic gluconeogenesis …

Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-
CoA thioesters. Thioesterase superfamily member (Them) 1 (synonym: Acot11) is enriched …

Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in
developed countries. NAFLD describes a wide range of liver pathologies from simple …

Background and Aims Obesity‐induced pathogenesis of nonalcoholic fatty liver disease
(NAFLD) and nonalcoholic steatohepatitis (NASH) is associated with increased de novo …

Acyl coenzyme A (acyl-CoA) thioesterases hydrolyze thioester bonds in acyl-CoA
metabolites. The majority of mammalian thioesterases are α/β-hydrolases and have been …

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver disease ranging from benign
steatosis (hepatocellular triglyceride [TG] accumulation of> 5% of liver weight) through …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease.
Triacylglycerol accumulation in the liver is a hallmark of NAFLD. Metabolic studies have …

Human carboxylesterase 2 (CES2) has triacylglycerol hydrolase (TGH) activities and plays
an important role in lipolysis. In this study, we aim to determine the role of human CES2 in …