Chronic wounds remain a serious clinical problem with insufficient therapeutic approaches.
In this study we investigated the dose dependency of rhVEGF165 in fibrin sealant in both …

Angiogenesis is a critical step of wound healing, and its failure leads to chronic wounds. The
idea of restoring blood flow to the damaged tissues by promoting neo-angiogenesis is …

BACKGROUND: In healing wounds, rising levels of vascular endothelial growth factor
(VEGF) induce a period of robust angiogenesis. The levels of pro-angiogenic factors in the …

Fibroblasts are the main cells of connective tissue and have pivotal roles in the proliferative
and maturation phases of wound healing. These cells can secrete various cytokines, growth …

This study investigated (1) the release of recombinant human vascular endothelial growth
factor ([rh] VEGF165) from an in vitro fibrin matrix,(2) the effects of (rh) VEGF165 released …

Objective—VEGF-ENZ7/PlGF molecules composed of Orf virus-derived VEGF-ENZ7 and
human PlGF1 were previously proven to be potent angiogenic factors stimulating …

Significance: Re-establishment of a functional vascular network is a critical component of
successful wound repair. One of the most potent pro-angiogenic agents is vascular …

Growth factors and/or angiogenic factors are supposed to improve wound healing. The aim
of our study was to evaluate the effects of subcutaneous pretreatment with combinatory …

BACKGROUND: A chronic wound is tissue with an impaired ability to heal. This is often a
consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency …

Soluble receptors to vascular endothelial growth factor (VEGF) can inhibit its angiogenic
effect. Since angiogenesis is involved in wound repair, we hypothesized that adenovirus …