[HTML][HTML] Downregulation of miR‑141 deactivates hepatic stellate cells by targeting the PTEN/AKT/mTOR pathway

H Liang, X Wang, C Si, Y Duan… - International …, 2020 - spandidos-publications.com
The activation of hepatic stellate cells (HSCs) caused by stimulating factors or fibrogenic
cytokines is the critical stage of liver fibrosis. Recent studies have demonstrated the …

[HTML][HTML] miR-345–5p curbs hepatic stellate cell activation and liver fibrosis progression by suppressing hypoxia-inducible factor-1alpha expression

P Wang, Y Fang, J Qiu, Y Zhou, Z Wang, C Jiang - Toxicology letters, 2022 - Elsevier
Hepatic fibrosis, as a common stage of multiple liver diseases, currently has no effective
drug treatment. Emerging evidence shows that miRNAs participate in the progression of liver …

MiR-15b and miR-16 suppress TGF-β1-induced proliferation and fibrogenesis by regulating LOXL1 in hepatic stellate cells

L Ma, J Liu, E Xiao, H Ning, K Li, J Shang, Y Kang - Life Sciences, 2021 - Elsevier
Activation of hepatic stellate cells (HSCs) is an important event during the progress of liver
fibrosis. MicroRNA (miR)-15b and miR-16 have been found to be involved in activation of …

[HTML][HTML] Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway

X Yang, L Ma, R Wei, T Ye, JK Zhou, M Wen… - Signal transduction and …, 2020 - nature.com
The activation of hepatic stellate cells (HSCs) participates in liver fibrosis, and emerging
evidences indicate that microRNAs (miRNAs) are abnormally expressed during HSC …

MiR-142-3p blocks TGF-β-induced activation of hepatic stellate cells through targeting TGFβRI

X Yang, X Dan, R Men, L Ma, M Wen, Y Peng, L Yang - Life sciences, 2017 - Elsevier
Aim To understand the contribution of miR-142-3p in the activation of hepatic stellate cells
(HSCs) and liver fibrosis, and the underlying mechanism. Materials and methods We …

MicroRNA‐28‐5p regulates liver cancer stem cell expansion via IGF‐1 pathway

Q Xia, T Han, P Yang, R Wang, H Li… - Stem Cells …, 2019 - Wiley Online Library
Background. MicroRNAs (miRNAs) play a critical role in the regulation of cancer stem cells
(CSCs). However, the role of miRNAs in liver CSCs has not been fully elucidated. Methods …

Liver microRNA-29b-3p positively correlates with relative enhancement values of magnetic resonance imaging and represses liver fibrosis

X Gong, X Wang, F Zhou - The journal of biochemistry, 2020 - academic.oup.com
This study aims to identify potential microRNAs (miRNAs) contribute to liver fibrosis
progression and investigate how the miRNA is involved. We recruited totally 58 patients …

[HTML][HTML] microRNA-34a and microRNA-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor γ

X Li, Y Chen, S Wu, J He, L Lou… - Molecular Medicine …, 2015 - spandidos-publications.com
Liver fibrosis is the common outcome of almost all cases of chronic liver disease. The
hallmark of liver fibrosis is the activation of hepatic stellate cells (HSCs). microRNA‑34a (miR …

[PDF][PDF] Promotion of hepatic stellate cell activation and liver fibrosis by microRNA-33a-5p through targeting the Dickkopf-1-mediated wingless-related integration site …

H Liu, S Zhang, Z Li, Z Zheng, W Shi, M Hu… - Journal of Physiology & …, 2023 - jpp.krakow.pl
Liver fibrosis occurs in response to chronic liver injury and is characterized by the production
of excess extracellular matrix (ECM) proteins, largely by activated hepatic stellate cells …

[HTML][HTML] MicroRNA-223 suppresses human hepatic stellate cell activation partly via regulating the actin cytoskeleton and alleviates fibrosis in organoid models of liver …

C Ariyachet, N Chuaypen, P Kaewsapsak… - International journal of …, 2022 - mdpi.com
MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate target mRNA
expression, and altered expression of miRNAs is associated with liver pathological …