DNA methylation mediated by DNA methyltransferase is an important epigenetic process
that regulates gene expression in mammals, which plays a key role in silencing certain …

The pharmacological inhibition of DNA methyltransferases provides novel opportunities for
the therapy of human cancers. Several Phase III trials of DNA methyltransferase inhibitors …

There is overwhelming evidence that DNA methylation patterns are altered in cancer.
Methylation of CG-rich islands in regulatory regions of genes marks them for transcriptional …

DNA methylation patterns are frequently altered in cancer cells as compared to normal cells.
A large body of research associates these DNA methylation aberrations with cancer …

DNA methyltransferases are promising targets for cancer therapy. In many cancer cells
promoters of tumor suppressor genes are hypermethylated, which results in gene …

DNA methylation is a mammalian epigenetic mark that participates to define where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

DNA methylation is an epigenetic modification involved in gene expression regulation. In
cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …

DNA methylation is now recognized as an important mechanism regulating different
functions of the genome; gene expression, replication, and cancer. Different factors control …

DNA methylation is one of the most essential epigenetic mechanisms to regulate gene
expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the …

Epigenetics refers to partially reversible, somatically inheritable, but DNA sequence-
independent traits that modulate gene expression, chromatin structure, and cell functions …