Male sex is a strong risk factor for autism spectrum disorder (ASD). The leading theory for a"
female protective effect"(FPE) envisions males and females have" differing thresholds" …

Autism spectrum disorders (ASDs) have long been noted to affect many more males than
females, and accordingly, sex-specific factors have been hypothesized to increase males' …

Autism spectrum disorder (ASD) is a developmental condition that affects approximately four
times as many males as females, a strong sex bias that has not yet been fully explained …

Background A 4: 1 male to female sex bias has consistently been observed in autism
spectrum disorder (ASD). Epidemiological and genetic studies suggest a female protective …

Sexual dimorphism in common disease is pervasive, including a dramatic male
preponderance in autism spectrum disorders (ASDs). Potential genetic explanations include …

Autism spectrum disorder (ASD) is diagnosed 3-4 times more frequently in males than in
females. Genetic studies of rare variants support a female protective effect (FPE) against …

Autism spectrum disorder (ASD) has historically been diagnosed more frequently in males
than females. One explanation for this is the 'female protective effect': that there is something …

Autism spectrum disorder (ASD) is diagnosed three to four times more frequently in males
than in females. Genetic studies of rare variants support a female protective effect (FPE) …

Abstract Background Autism spectrum disorders (ASDs) are more prevalent in males,
suggesting a multiple threshold liability model in which females are, on average, protected …

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a male-to-
female prevalence of 4: 1. However, the genetic mechanisms underlying this gender …