Peripheral brain derived neurotrophic factor precursor regulates pain as an inflammatory mediator
C Luo, XL Zhong, FH Zhou, J Li, P Zhou, JM Xu… - Scientific reports, 2016 - nature.com
The precursor of brain derived neurotrophic factor (proBDNF), the unprocessed BDNF gene
product, binds to its receptors and exerts the opposing biologic functions of mature BDNF …
product, binds to its receptors and exerts the opposing biologic functions of mature BDNF …
Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain
J Zhao, A Seereeram, MA Nassar, A Levato… - Molecular and Cellular …, 2006 - Elsevier
Conditional mouse knock-outs provide an informative approach to drug target validation
where no pharmacological blockers exist or global knock-outs are lethal. Here, we used the …
where no pharmacological blockers exist or global knock-outs are lethal. Here, we used the …
BDNF in sensory neurons and chronic pain
K Obata, K Noguchi - Neuroscience research, 2006 - Elsevier
Neurotrophic factors, which support neuronal survival and growth during development of the
nervous system, have been shown to play significant roles in the transmission of physiologic …
nervous system, have been shown to play significant roles in the transmission of physiologic …
Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain
S Sikandar, MS Minett, Q Millet, S Santana-Varela… - Brain, 2018 - academic.oup.com
Many studies support the pro-nociceptive role of brain-derived neurotrophin factor (BDNF) in
pain processes in the peripheral and central nervous system. We have previously shown …
pain processes in the peripheral and central nervous system. We have previously shown …
Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord
Central sensitization, the hyperexcitability of spinal processing that often accompanies
peripheral injury, is a major component of many persistent pain states. Here we report that …
peripheral injury, is a major component of many persistent pain states. Here we report that …
Epigenetic regulation of BDNF expression in the primary sensory neurons after peripheral nerve injury: implications in the development of neuropathic pain
H Uchida, Y Matsushita, H Ueda - Neuroscience, 2013 - Elsevier
Brain-derived neurotrophic factor (BDNF) is known to be up-regulated in the dorsal root
ganglion (DRG) after peripheral nerve injury, and to contribute to neuropathic pain. Here, we …
ganglion (DRG) after peripheral nerve injury, and to contribute to neuropathic pain. Here, we …
The role of the brain-derived neurotrophic factor in chronic pain: links to central sensitization and neuroinflammation
HY Xiong, J Hendrix, S Schabrun, A Wyns… - Biomolecules, 2024 - mdpi.com
Chronic pain is sustained, in part, through the intricate process of central sensitization (CS),
marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain …
marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain …
Up-Regulation of ProBDNF/p75NTR Signaling in Spinal Cord Drives Inflammatory Pain in Male Rats
H Li, T Liu, J Sun, S Zhao, X Wang, W Luo… - Journal of …, 2023 - Taylor & Francis
Background The spinal cord expresses brain-derived neurotrophic factor precursor
(proBDNF) and its receptor pan neurotrophin receptor 75 (p75NTR). However, the role of …
(proBDNF) and its receptor pan neurotrophin receptor 75 (p75NTR). However, the role of …
Expression of brain-derived neurotrophic factor in rat dorsal root ganglia, spinal cord and gracile nuclei in experimental models of neuropathic pain
SO Ha, JK Kim, HS Hong, DS Kim, HJ Cho - Neuroscience, 2001 - Elsevier
Chronic constriction injury of the sciatic nerve and lumbar L5 and L6 spinal nerve ligation
provide animal models for pain syndromes accompanying peripheral nerve injury and …
provide animal models for pain syndromes accompanying peripheral nerve injury and …
Inflammation and activity augment brain-derived neurotrophic factor peripheral release
Brain-derived neurotrophic factor (BDNF) release to nerve terminals in the central nervous
system is crucial in synaptic transmission and neuronal plasticity. However, BDNF release …
system is crucial in synaptic transmission and neuronal plasticity. However, BDNF release …