The precursor of brain derived neurotrophic factor (proBDNF), the unprocessed BDNF gene
product, binds to its receptors and exerts the opposing biologic functions of mature BDNF …

Conditional mouse knock-outs provide an informative approach to drug target validation
where no pharmacological blockers exist or global knock-outs are lethal. Here, we used the …

Neurotrophic factors, which support neuronal survival and growth during development of the
nervous system, have been shown to play significant roles in the transmission of physiologic …

Many studies support the pro-nociceptive role of brain-derived neurotrophin factor (BDNF) in
pain processes in the peripheral and central nervous system. We have previously shown …

Central sensitization, the hyperexcitability of spinal processing that often accompanies
peripheral injury, is a major component of many persistent pain states. Here we report that …

Brain-derived neurotrophic factor (BDNF) is known to be up-regulated in the dorsal root
ganglion (DRG) after peripheral nerve injury, and to contribute to neuropathic pain. Here, we …

Chronic pain is sustained, in part, through the intricate process of central sensitization (CS),
marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain …

Background The spinal cord expresses brain-derived neurotrophic factor precursor
(proBDNF) and its receptor pan neurotrophin receptor 75 (p75NTR). However, the role of …

Chronic constriction injury of the sciatic nerve and lumbar L5 and L6 spinal nerve ligation
provide animal models for pain syndromes accompanying peripheral nerve injury and …

Brain-derived neurotrophic factor (BDNF) release to nerve terminals in the central nervous
system is crucial in synaptic transmission and neuronal plasticity. However, BDNF release …