Aims: To test that the osteogenic capacity of periodontal ligament (PDL) fibroblasts can be
mediated by TLR2 and TLR4 activation. Materials and Methods: Human PDL fibroblasts …

Background This study investigated the effects of Toll‐like receptors (TLRs) on human
periodontal ligament stem cells (hPDLSCs) osteogenic differentiation and the associated …

Periodontal ligament stem cells (PDLSCs) plays an important role in tissue engineering. As
the age increased, the cell viability and osteogenic differentiation of PDLSCs all decreased …

The aim of the present study was to assess the roles of periodontal ligament‑associated
protein‑1 (PLAP‑1) in the osteogenic differentiation of rat bone marrow stromal cells …

Periodontitis is characterized by periodontal destruction triggered by chronic inflammation.
The optimal treatment for periodontitis is to improve the periodontal microenvironment …

Abstract Toll‑like receptor 4 (TLR4) is a transmembrane receptor responsible for the
activation of a number of signal transduction pathways. Despite its involvement in …

During orthodontic tooth movement, mechanical forces acting on periodontal ligament (PDL)
cells induce the synthesis of mediators which alter the growth, differentiation, and secretory …

Background Toll‐like receptor 4 (TLR4)‐mediated inflammatory responses are associated
with diabetes and periodontitis, which are dysregulated by O‐GlcNAcylation. Objective This …

Transforming growth factor beta (TGF-β) is a multi-functional growth factor expressed in
many tissues and organs. Genetic animal models have revealed the critical functions of TGF …

Periodontal ligament (PDL) is one of the most important tissues in maintaining the
homeostasis of tooth and tooth-supporting tissue, periodontium. In this study, we …