Dear Editor, We congratulate Mallédant et al.[1] for their thorough update on several key
questions regarding severe acute pancreatitis (SAP; Table 1). We agree that assessment of …

Objectives: In severe acute pancreatitis, the administration of fluids in the presence of
positive fluid responsiveness is associated with better outcome when compared to guiding …

Background Fluid resuscitation is one of the main therapies for acute pancreatitis (AP).
There is still no consensus on the type of fluid resuscitation. This study investigated the …

FV48 increased mortality and a high FVR decreased mortality in patients with severe acute
pancreatitis. A high FV48 required ventilation in patients with severe acute pancreatitis …

Aims: Guidelines recommend aggressive fluid resuscitation in patients with acute
pancreatitis (AP) to minimize organ failure. This study aimed to determine whether early …

The potentially harmful side effects of fluid accumulation in critical illness were highlighted in
numerous publications over the past years [1, 2]. Only recently another large RCT …

Fluid therapy/resuscitation is mandatory in acute pancreatitis due to the pathophysiology of
fluid loss as a consequence of the inflammatory process. For many years, without clear …

Objectives We aimed to perform a systematic review and meta-analysis of randomized
controlled trials to summarize the overall association between the choice of fluid (lactated …

Overall, this review is a bit discouraging for the reader looking for data-driven advice that
can be used clinically. Some of these findings are, at first glance, surprising. For instance …