We asked whether the physiological and morphologic properties of hypoglossal motor
neurons (CNXII MNs) that innervate protruder or retractor tongue muscles are disrupted in …

Abstract DiGeorge/22q11. 2 Deletion Syndrome (22q11DS) is a common genetic
microdeletion syndrome that underlies several neurodevelopmental disorders including …

Pediatric dysphagia—feeding and swallowing difficulties that begin at birth, last throughout
childhood, and continue into maturity—is one of the most common, least understood …

We assessed feeding-related developmental anomalies in the LgDel mouse model of
chromosome 22q11 deletion syndrome (22q11DS), a common developmental disorder that …

Disrupted development of oropharyngeal structures as well as cranial nerve and brainstem
circuits may lead to feeding and swallowing difficulties in children with 22q11. 2 deletion …

We identified divergent modes of initial axon growth that prefigure disrupted differentiation of
the trigeminal nerve (CN V), a cranial nerve essential for suckling, feeding and swallowing …

LgDel mice, which model the heterozygous deletion of genes at human chromosome 22q11.
2 associated with DiGeorge/22q11. 2 deletion syndrome (22q11DS), have cranial nerve and …

ABSTRACT 22q11. 2 Deletion Syndrome (22q11DS) is a neurodevelopmental disorder
associated with cranial nerve anomalies and disordered oropharyngeal function, including …

There are increased risks for deglutition disorders in people with Down syndrome (DS).
Although mouse models have been used to study the biological underpinnings of DS in …

Purpose Down syndrome (DS) is a developmental disability associated with difficulties in
deglutition. The adult Ts65Dn mouse model of DS has been previously shown to have …