Melatonin is a molecule with different antitumor actions in breast cancer and has been
described as an inhibitor of vascular endothelial growth factor (VEGF). Despite the …

Endothelial cells represent one of the critical cellular elements in tumor microenvironment
playing a crucial role in the growth and progression of cancer through controlling …

As neovascularization is essential for tumor growth and metastasis, controlling angiogenesis
is a promising tactic in limiting cancer progression. Melatonin has been studied for their …

Melatonin exerts oncostatic activity in breast cancer through antiangiogenic actions. There,
the aim of the present study was to ascertain whether melatonin modulates, in a coordinated …

Angiogenesis is the process of new blood vessel formation, regulated by a number of pro-
and antiangiogenic factors and usually begins in response to hypoxia. Exogenous …

Melatonin is an important natural oncostatic agent, and our previous studies have found its
inhibitory action on tumor angiogenesis, but the mechanism remains unclear. It is well …

Melatonin, a pineal indolamine, participates in different body functions and is shown to
possess diverse biological activities such as anti-tumor action. Angiogenesis inhibition is …

Excessive concentrations of vascular endothelial growth factor (VEGF) trigger angiogenesis,
which causes complications such as the destabilization of atherosclerotic plaques and …

Chemotherapeutics are sometimes administered with drugs, like antiangiogenic
compounds, to increase their effectiveness. Melatonin exerts antitumoral actions through …

Melatonin exerts oncostatic effects on breast cancer by interfering with the estrogen‐
signaling pathways. Melatonin reduces estrogen biosynthesis in human breast cancer cells …