Uric acid is the end product of purine catabolism in humans and is capable of acting as both
an antioxidant scavenging reactive oxygen species and conditionally a pro‐oxidant …

The development of the kidney involves essential cellular processes, such as cell
proliferation and differentiation, which are led by interactions between multiple signaling …

Uric acid (UA) is the final metabolite in purine catabolism in humans. Previous studies have
shown that the dysregulation of UA homeostasis is detrimental to cardiovascular and kidney …

Uric acid (UA), the end-product of purine catabolism in humans acts as an antioxidant in
circulation by scavenging free radicals1. However, UA can also be considered a conditional …

Chronic kidney disease (CKD) is characterized by renal fibrosis that can lead to end-stage
renal failure, and studies have supported a strong genetic influence on the risk of …

Background: Uric acid (UA), the end-product of human purine catabolism, is produced using
xanthine dehydrogenase (XDH) and xanthine oxidase enzymes. Both enzymes are encoded …

Xanthine Oxidoreductase (XOR) is a ubiquitous, essential enzyme responsible for the
terminal steps of purine catabolism, ultimately producing uric acid that is eliminated by the …

Xanthine oxidoreductase (XD: xanthine dehydrogenase+ xanthine oxidase) is a complex
enzyme that catalyzes oxidation of hypoxathine to xanthine, subsequently producing uric …

Several rare genetic variations of human XDH have been shown to alter xanthine
oxidoreductase (XOR) activity leading to impaired purine catabolism. However, XOR is a …

Xanthine oxidoreductase (XOR) is an enzyme responsible for purine degradation, reactive
oxygen species production, and adipogenesis. XOR gene-disrupted (XOR−/−) mice …